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dc.contributor.authordeCarvalho, H. F.
dc.contributor.authorTaboga, SR
dc.contributor.authorVilamaior, PSL
dc.date.accessioned2014-05-20T15:28:02Z
dc.date.available2014-05-20T15:28:02Z
dc.date.issued1997-04-01
dc.identifierhttp://dx.doi.org/10.1016/S0040-8166(97)80016-X
dc.identifier.citationTissue & Cell. Edinburgh: Churchill Livingstone, v. 29, n. 2, p. 163-170, 1997.
dc.identifier.issn0040-8166
dc.identifier.urihttp://hdl.handle.net/11449/37946
dc.description.abstractStroma-epithelium relationships are of great relevance in prostatic morphogenesis and physiology, However, little knowledge exists about either stromal cells or extracellular matrix composition and arrangement in this system, Ultrastructural analysis revealed the existence of a microfibrillar system which occupies large areas of the rat prostatic stroma, In this work, we have applied immunocytochemistry and an ATP treatment for the ultrastructural identification of collagen type VI microfibrils, aiming at examining its participation in the prostatic microfibrillar network. Immunocytochemistry was also extended to a human case of prostatic nodular hyperplasia, Both methods succeeded in identifying collagen type VI in the rat ventral prostate, Collagen type VI is evenly distributed throughout the stroma but mainly associated with the basal lamina, collagen fibrils, and around the stromal cells, the use of ATP treatment allowed for the discrimination between collagen type VI and elastin-associated microfibrils, and demonstrated that these two classes of microfibrils establish an extended, mixed, and open network. The same aspects of association with the basal lamina, with stromal cells (particularly with smooth muscle cells), and with fibrillar components of the stroma were observed in the human tissue, We suggest that the collagen type VI and elastin-associated microfibril system may be involved in the control of some aspects of cellular behavior and may also play a structural role, maintaining the organ integrity after the deformations occurring under smooth muscle contraction.en
dc.format.extent163-170
dc.language.isoeng
dc.publisherChurchill Livingstone
dc.relation.ispartofTissue & Cell
dc.sourceWeb of Science
dc.subjectcollagen type VIpt
dc.subjectprostatept
dc.subjectimmunocytochemistrypt
dc.subjectextracellular matrixpt
dc.subjectmicrofibrilspt
dc.titleCollagen type VI is a component of the extracellular matrix microfibril network of the prostatic stromaen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderChurchill Livingstone
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationUNESP,IBILCE,DEPT BIOL,S JOSE RIO PR,SP,BRAZIL
dc.description.affiliationUnespUNESP,IBILCE,DEPT BIOL,S JOSE RIO PR,SP,BRAZIL
dc.identifier.doi10.1016/S0040-8166(97)80016-X
dc.identifier.wosWOS:A1997WY25400003
dc.rights.accessRightsAcesso restrito
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt
dc.identifier.lattes1445259468526188
dc.identifier.lattes7066358123790434
dc.identifier.orcid0000-0002-0970-4288
dc.identifier.orcid0000-0001-9559-5497
unesp.author.lattes1445259468526188
unesp.author.lattes7066358123790434[3]
unesp.author.orcid0000-0001-9559-5497[3]
unesp.author.orcid0000-0002-0970-4288[2]
dc.relation.ispartofjcr1.438
dc.relation.ispartofsjr0,410
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