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dc.contributor.authorPimenta, W. P.
dc.contributor.authorCalderon, Iracema de Mattos Paranhos [UNESP]
dc.contributor.authorCruz, N. S.
dc.contributor.authorSantos, M. L.
dc.contributor.authorAragon, F. F.
dc.contributor.authorPadovani, Carlos Roberto [UNESP]
dc.date.accessioned2014-05-20T15:29:06Z
dc.date.available2014-05-20T15:29:06Z
dc.date.issued2004-12-01
dc.identifierhttp://dx.doi.org/10.1111/j.0001-6349.2004.00444.x
dc.identifier.citationActa Obstetricia Et Gynecologica Scandinavica. Copenhagen: Blackwell Munksgaard, v. 83, n. 12, p. 1152-1158, 2004.
dc.identifier.issn0001-6349
dc.identifier.urihttp://hdl.handle.net/11449/38758
dc.description.abstractBackground. To evaluate insulin release and insulin sensitivity in women with prior gestational diabetes mellitus (GDM) to gain a better understanding of type 2 diabetes pathogenesis.Methods. GDM women were individually matched for age, body mass index, and waist/hip ratio with those who were normal glucose tolerant in a previous pregnancy (NGT). All women presented with normal glucose tolerance. Twenty pairs were submitted to the oral glucose tolerance test (OGTT) with plasma glucose, insulin, and C-peptide determinations. of the 20 pairs, 18 participated in hyperglycemic (10.0 mmol/l) clamp experiments with frequent plasma glucose and insulin determinations, allowing us to calculate first- and second-phase insulin release and the insulin sensitivity index. GDM and NGT women were compared using Student's t-test, the Mann-Whitney U-test, Friedman's non-parametric test, and the two proportion test for independent groups.Results. GDM women showed higher glycosylated hemoglobin values; at OGTT, they showed late insulin peak with increased plasma insulin levels only during the second hour, and a similar plasma C-peptide response despite a higher plasma glucose curve; during hyperglycemic clamp procedures, they showed similar biphasic insulin release and insulin sensitivity index. Considering that a woman with previous GDM had a defect in insulin release and/or insulin sensitivity, if its magnitude was at least 25% lower than that of the matched NGT woman, 43.8% showed impairment of first-phase insulin release and 55.6% insulin resistance.Conclusions. GDM women showed some degree of glucose intolerance. It is therefore necessary to follow them for a longer time.en
dc.format.extent1152-1158
dc.language.isoeng
dc.publisherBlackwell Munksgaard
dc.relation.ispartofActa Obstetricia et Gynecologica Scandinavica
dc.sourceWeb of Science
dc.subjectgestational diabetes mellituspt
dc.subjectinsulin secretionpt
dc.subjectinsulin sensitivitypt
dc.titleSubclinical abnormalities of glucose metabolism in Brazilian women with a history of gestational diabetes mellitusen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderBlackwell Munksgaard
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationSão Paulo State Univ, Botucatu Inst Biosci, Div Biostat, Botucatu, SP, Brazil
dc.description.affiliationSão Paulo State Univ, Botucatu Sch Med, Div Internal Med, Botucatu, SP, Brazil
dc.description.affiliationSão Paulo State Univ, Botucatu Sch Med, Div Obstet & Gynecol, Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Botucatu Inst Biosci, Div Biostat, Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Botucatu Sch Med, Div Internal Med, Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Botucatu Sch Med, Div Obstet & Gynecol, Botucatu, SP, Brazil
dc.identifier.doi10.1111/j.0001-6349.2004.00444.x
dc.identifier.wosWOS:000225576200011
dc.rights.accessRightsAcesso restrito
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
dc.identifier.lattes0679387622604743
dc.identifier.lattes8727897080522289
unesp.author.lattes0679387622604743
unesp.author.lattes8727897080522289
unesp.author.orcid0000-0002-7719-9682[6]
unesp.author.orcid0000-0003-4761-4336[2]
dc.relation.ispartofjcr2.649
dc.relation.ispartofsjr1,283
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