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dc.contributor.authorVilani-Moreno, Fatima Regina
dc.contributor.authorFernandes Belone, Andrea de Faria
dc.contributor.authorLara, Vanessa Soares
dc.contributor.authorVenturini, James [UNESP]
dc.contributor.authorPereira Lauris, Jose Roberto
dc.contributor.authorSoares, Cleverson Teixeira
dc.date.accessioned2014-05-20T15:31:43Z
dc.date.available2014-05-20T15:31:43Z
dc.date.issued2011-08-01
dc.identifierhttp://dx.doi.org/10.3109/13693786.2010.547993
dc.identifier.citationMedical Mycology. London: Informa Healthcare, v. 49, n. 6, p. 643-648, 2011.
dc.identifier.issn1369-3786
dc.identifier.urihttp://hdl.handle.net/11449/40783
dc.description.abstractStudies investigating the immunopathological aspects of Jorge Lobo's disease have shown that the inflammatory infiltrate consists mainly of histiocytes and multinucleated giant cells involving numerous yeast-like cells of Lacazia loboi, with the T lymphocytes more common than B lymphocytes and plasma cells. The quantification of cytokines in peripheral blood mononuclear cells culture supernatant has revealed alterations in the cytokines profile, characterized by predominance of a Th2 profile. In view of these findings and of the role of cytokines in cell interactions, the objective of the present study was to investigate the presence of the cytokines IL-10, TGF-ss 1 and TNF-alpha, as well as iNOS enzyme in granulomas induced by L. loboi. Histological sections obtained from skin lesions of 16 patients were analyzed by immunohistochemistry for the presence of these cytokines and iNOS. The results showed that TGF-ss 1 was the cytokine most frequently expressed by cells present in the inflammatory infiltrate, followed by IL-10. There was a minimum to discrete positivity of cells expressing TNF-alpha and iNOS. The results suggest that the presence of immunosuppressive cytokines in skin lesions of patients with the mycosis might be responsible for the lack of containment of the pathogen as demonstrated by the presence of numerous fungi in the granuloma.en
dc.format.extent643-648
dc.language.isoeng
dc.publisherInforma Healthcare
dc.relation.ispartofMedical Mycology
dc.sourceWeb of Science
dc.subjectJorge Lobo's diseaseen
dc.subjectLacazia loboien
dc.subjectcytokinesen
dc.subjectiNOS enzymeen
dc.subjectimmunohistochemistryen
dc.titleDetection of cytokines and nitric oxide synthase in skin lesions of Jorge Lobo's disease patientsen
dc.typeArtigo
dcterms.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dcterms.rightsHolderInforma Healthcare
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.description.affiliationInst Lauro de Souza Lima, Equipe Tecn Biol, Bauru, SP, Brazil
dc.description.affiliationInst Lauro de Souza Lima, Equipe Tecn Patol, Bauru, SP, Brazil
dc.description.affiliationUniv São Paulo, Fac Odontol, Bauru, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias, Bauru, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias, Bauru, SP, Brazil
dc.identifier.doi10.3109/13693786.2010.547993
dc.identifier.wosWOS:000292780000011
dc.rights.accessRightsAcesso restrito
unesp.author.orcid0000-0003-3475-4479[5]
unesp.author.orcid0000-0003-0035-2439[4]
dc.relation.ispartofjcr2.799
dc.relation.ispartofsjr0,973
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