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dc.contributor.authorMonteiro, Eduardo R. [UNESP]
dc.contributor.authorTeixeira Neto, Francisco José [UNESP]
dc.contributor.authorCampagnol, Daniela [UNESP]
dc.contributor.authorAlvaides, Renata K. [UNESP]
dc.contributor.authorGarofalo, Natache A. [UNESP]
dc.contributor.authorMatsubara, Lidia M. [UNESP]
dc.identifier.citationAmerican Journal of Veterinary Research. Schaumburg: Amer Veterinary Medical Assoc, v. 71, n. 2, p. 150-156, 2010.
dc.description.abstractObjective-To evaluate the effects of remifentanil on isoflurane minimum alveolar concentration (ISO(MAC)) in dogs.Animals-6 adult mixed-breed dogs.Procedures-Dogs were anesthetized with isoflurane on 2 occasions. During the first set of experiments, ISO(MAC) was determined before remifentanil infusion (baseline), during constant rate infusion (M of remifentanil (0.15, 0.30, 0.60, and 0.90 mu g/kg/min), and 80 minutes after remifentanil infusion. After a 1-week washout period, dogs received a CRI of remifentanil (0.15 mu g/kg/min) and ISO(MAC) was redetermined 2, 4, and 6 hours after commencing the infusion.Results-Mean +/- SD baseline ISO(MAC) was 1.24 +/- 0.18%. Remifentanil infusion (0.15, 0.30, 0.60, and 0.90 mu g/kg/min) decreased ISO(MAC) by 43 +/- 10%, 59 +/- 10%, 66 +/- 9%, and 71 +/- 9%, respectively. The ISO(MAC) values determined during the 0.30, 0.60, and 0.90 mu g/kg/min infusion rates did not differ from each other, but these values were significantly lower, compared with the 0.15 mu g/kg/min infusion rate. The ISO(MAC) recorded after remifentanil infusion 0.09 +/- 0.18%) did not differ from baseline ISO(MAC). There was no change in ISO(MAC) throughout the 6-hour period of a CRI of remifentanil.Conclusions and Clinical Relevance-Remifentanil decreased ISO(MAC) in a dose-related fashion; the reduction in ISO(MAC) was stable over the course of a prolonged CRI (6 hours). A dose of 0.30 mu g of remifentanil/kg/min resulted in nearly maximal isoflurane-sparing effect in dogs; a ceiling effect was observed at higher infusion rates. (Am J Vet Res 2010;71:150156)en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.publisherAmer Veterinary Medical Assoc
dc.relation.ispartofAmerican Journal of Veterinary Research
dc.sourceWeb of Science
dc.titleEffects of remifentanil on the minimum alveolar concentration of isoflurane in dogsen
dcterms.rightsHolderAmer Veterinary Medical Assoc
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationUniv Estadual Paulista, UNESP, Fac Med Vet & Zootecnia, Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Fac Med, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Fac Med Vet & Zootecnia, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Fac Med, Botucatu, SP, Brazil
dc.rights.accessRightsAcesso restrito
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt[2]
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