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dc.contributor.authorMonteiro, Eduardo R. [UNESP]
dc.contributor.authorTeixeira Neto, Francisco José [UNESP]
dc.contributor.authorCampagnol, Daniela [UNESP]
dc.contributor.authorAlvaides, Renata K. [UNESP]
dc.contributor.authorGarofalo, Natache A. [UNESP]
dc.contributor.authorMatsubara, Lidia M. [UNESP]
dc.date.accessioned2014-05-20T15:31:56Z
dc.date.available2014-05-20T15:31:56Z
dc.date.issued2010-02-01
dc.identifierhttp://dx.doi.org/10.2460/ajvr.71.2.150
dc.identifier.citationAmerican Journal of Veterinary Research. Schaumburg: Amer Veterinary Medical Assoc, v. 71, n. 2, p. 150-156, 2010.
dc.identifier.issn0002-9645
dc.identifier.urihttp://hdl.handle.net/11449/40947
dc.description.abstractObjective-To evaluate the effects of remifentanil on isoflurane minimum alveolar concentration (ISO(MAC)) in dogs.Animals-6 adult mixed-breed dogs.Procedures-Dogs were anesthetized with isoflurane on 2 occasions. During the first set of experiments, ISO(MAC) was determined before remifentanil infusion (baseline), during constant rate infusion (M of remifentanil (0.15, 0.30, 0.60, and 0.90 mu g/kg/min), and 80 minutes after remifentanil infusion. After a 1-week washout period, dogs received a CRI of remifentanil (0.15 mu g/kg/min) and ISO(MAC) was redetermined 2, 4, and 6 hours after commencing the infusion.Results-Mean +/- SD baseline ISO(MAC) was 1.24 +/- 0.18%. Remifentanil infusion (0.15, 0.30, 0.60, and 0.90 mu g/kg/min) decreased ISO(MAC) by 43 +/- 10%, 59 +/- 10%, 66 +/- 9%, and 71 +/- 9%, respectively. The ISO(MAC) values determined during the 0.30, 0.60, and 0.90 mu g/kg/min infusion rates did not differ from each other, but these values were significantly lower, compared with the 0.15 mu g/kg/min infusion rate. The ISO(MAC) recorded after remifentanil infusion 0.09 +/- 0.18%) did not differ from baseline ISO(MAC). There was no change in ISO(MAC) throughout the 6-hour period of a CRI of remifentanil.Conclusions and Clinical Relevance-Remifentanil decreased ISO(MAC) in a dose-related fashion; the reduction in ISO(MAC) was stable over the course of a prolonged CRI (6 hours). A dose of 0.30 mu g of remifentanil/kg/min resulted in nearly maximal isoflurane-sparing effect in dogs; a ceiling effect was observed at higher infusion rates. (Am J Vet Res 2010;71:150156)en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent150-156
dc.language.isoeng
dc.publisherAmer Veterinary Medical Assoc
dc.relation.ispartofAmerican Journal of Veterinary Research
dc.sourceWeb of Science
dc.titleEffects of remifentanil on the minimum alveolar concentration of isoflurane in dogsen
dc.typeArtigo
dcterms.licensehttps://www.avma.org/Pages/terms-of-use.aspx
dcterms.rightsHolderAmer Veterinary Medical Assoc
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationUniv Estadual Paulista, UNESP, Fac Med Vet & Zootecnia, Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Fac Med, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Fac Med Vet & Zootecnia, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Fac Med, Botucatu, SP, Brazil
dc.identifier.doi10.2460/ajvr.71.2.150
dc.identifier.wosWOS:000274215300003
dc.rights.accessRightsAcesso restrito
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt
unesp.author.orcid0000-0002-3002-8093[2]
dc.relation.ispartofjcr0.833
dc.relation.ispartofsjr0,567
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