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dc.contributor.authorShiogiri, Natalia S.
dc.contributor.authorPaulino, Marcelo G.
dc.contributor.authorCarraschi, Silvia P. [UNESP]
dc.contributor.authorBaraldi, Flavia G.
dc.contributor.authorda Cruz, Claudinei
dc.contributor.authorFernandes, Marisa Narciso
dc.date.accessioned2014-05-20T15:32:32Z
dc.date.available2014-05-20T15:32:32Z
dc.date.issued2012-09-01
dc.identifierhttp://dx.doi.org/10.1016/j.etap.2012.05.007
dc.identifier.citationEnvironmental Toxicology and Pharmacology. Amsterdam: Elsevier B.V., v. 34, n. 2, p. 388-396, 2012.
dc.identifier.issn1382-6689
dc.identifier.urihttp://hdl.handle.net/11449/41412
dc.description.abstractThe aim of this study was to determine the acute toxicity of Roundup (R) Ready (RR) in Piaractus mesopotamicus, and evaluate the effects on the morphology of the gills and liver of exposed surviving fish. Fish were exposed to 3.0, 3.5, 4.0 and 4.5 mg L-1 of glyphosate, and the LC50;48 h was estimated at 3.74 +/- 0.2 mg L-1. Gill histopathology was rare, and the activity of Na+/K+-ATPase enzyme did not change, suggesting normal function. However, the damage to the liver was classified as moderate to severe. Cytoplasmic vacuolization, lipid accumulation, nuclear and cellular membrane alterations and glycogen depletion were found in the liver, suggesting a reduction in the liver function. The glyphosate in the RR formulation was classified as moderately toxic for P. mesopotamicus, and the severe damage in the liver may affect the detoxification and/or tissue repair process and contribute to fish death. (C) 2012 Elsevier B.V. All rights reserved.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent388-396
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofEnvironmental Toxicology and Pharmacology
dc.sourceWeb of Science
dc.subjectHerbicideen
dc.subjectHistopathologyen
dc.subjectImmunohistochemistryen
dc.subjectLethal concentrationen
dc.subjectTeleosten
dc.titleAcute exposure of a glyphosate-based herbicide affects the gills and liver of the Neotropical fish, Piaractus mesopotamicusen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationUniversidade Federal de São Carlos (UFSCar), Programa Posgrad Ecol & Recursos Nat, BR-13565905 São Carlos, SP, Brazil
dc.description.affiliationUniversidade Federal de São Carlos (UFSCar), Dept Ciencias Fisiol, BR-13565905 São Carlos, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Dept Fitosanindade, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Fitosanindade, São Paulo, Brazil
dc.identifier.doi10.1016/j.etap.2012.05.007
dc.identifier.wosWOS:000313155600032
dc.rights.accessRightsAcesso restrito
dc.description.sponsorshipIdFAPESP: 09/04508-3
dc.description.sponsorshipIdCNPq: 573949/2008-5
unesp.author.orcid0000-0003-4064-0718[5]
dc.relation.ispartofjcr2.776
dc.relation.ispartofsjr0,813
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