An immunohistochemical study of interleukin-8 (IL-8) in breast cancer
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Data
2012-01-01
Autores
Pires de Campos Zuccari, Debora Aparecida
Leonel, Camila [UNESP]
Castro, Rodrigo
Gelaleti, Gabriela Bottaro [UNESP]
Jardim, Bruna Victorasso [UNESP]
Moscheta, Marina Gobbe
Regiani, Vitor Rafael
Ferreira, Livia Carvalho
Lopes, Juliana Ramos [UNESP]
Neto, Dalisio de Santi
Título da Revista
ISSN da Revista
Título de Volume
Editor
Elsevier Gmbh, Urban & Fischer Verlag
Resumo
The use of prognostic markers for breast cancer is important for routine diagnosis and research. Interleukin-8 is a chemotactic cytokine produced by several cell types in response to inflammation, however, its expression, regulation and function are poorly understood. Recent studies have associated angiogenesis and inflammatory processes with tumor malignancy. The present study investigated the correlation between interleukin-8 expression and breast cancer prognosis. Interleukin-8 expression was assessed in 72 women with mammary neoplasia by immunohistochemistry and the results were statistically correlated with clinical-pathological findings. There was an inverse correlation between interleukin-8 expression and metastasis (p = 0.03) and/or local recurrence (p = 0.02). In the patient group that received post-surgery chemotherapy and radiotherapy, a lower interleukin-8 expression was found in those women that showed local recurrence (p = 0.01). Multivariate logistic regression showed estrogen receptor negativity, progesterone positivity and metastasis with increased risk of death (p < 0.05). The data reflect the complexity of the role of interleukin-8 in tumor microenvironment and support its classification as a possible prognostic marker, although more studies are necessary for its inclusion in clinical practice. Crown Copyright (C) 2011 Published by Elsevier GmbH. All rights reserved.
Descrição
Palavras-chave
Breast cancer, Women, Interleukin-8, Immunohistochemistry, Prognostics
Como citar
Acta Histochemica. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 114, n. 6, p. 571-576, 2012.