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dc.contributor.authorChung, Hae-Yun
dc.contributor.authorFerreira, Ana Lúcia dos Anjos [UNESP]
dc.contributor.authorEpstein, Susanna
dc.contributor.authorPaiva, Sergio Alberto Rupp de [UNESP]
dc.contributor.authorCastaneda-Sceppa, Carmen
dc.contributor.authorJohnson, Elizabeth J.
dc.identifier.citationAmerican Journal of Clinical Nutrition. Bethesda: Amer Soc Clinical Nutrition, v. 90, n. 3, p. 533-539, 2009.
dc.description.abstractBackground: Dietary carotenoids are related to a decreased risk of certain diseases. Serum and adipose tissue carotenoid concentrations are used as biomarkers of intake.Objectives: The objectives of this study were to evaluate site-specific concentrations of carotenoids in adipose tissue and to examine relations between carotenoid concentrations in the diet, serum, and adipose tissue.Design: Healthy adults (12 women and 13 men) participated in this cross-sectional study. Dietary carotenoids over the past year were assessed with a food-frequency questionnaire. Serum and adipose tissue biopsy samples were collected from the abdomen, buttock, and inner thigh for the measurement of carotenoids by HPLC.Results: Many adipose carotenoids were inversely related to percentage body fat, although lycopene was the only carotenoid inversely correlated with all 3 sites. Most of the carotenoids were significantly higher in the abdominal adipose tissue than in the thigh (P < 0.05). Concentrations of alpha-carotene, beta-carotene, 5-cis-lycopene, and total carotenoids were significantly higher in the buttocks than in the thigh (P < 0.05). Concentrations of alpha-carotene, cis-lycopene, and lutein (with or without zeaxanthin) were significantly higher in the abdomen than in the buttocks (P < 0.05). Dietary intake was significantly correlated with serum concentrations of alpha-carotene, beta-carotene, beta-cryptoxanthin, and total carotenoids. Carotenoid intake was significantly correlated with adipose tissue concentrations of alpha-carotene, beta-carotene, beta-cryptoxanthin, cis-lycopene, and total carotenoids (P < 0.05) but varied by site. of all the adipose tissue sites evaluated, the abdomen showed the strongest correlation with long-term dietary carotenoid intakes and with serum (indicator of short-term intake) for most carotenoids.Conclusions: Body fat may influence the tissue distribution of carotenoids. Abdominal adipose tissue carotenoid concentrations may be a useful indicator of carotenoid status. Am J Clin Nutr 2009;90:533-9.en
dc.description.sponsorshipUS Department of Agriculture
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.publisherAmer Soc Clinical Nutrition
dc.relation.ispartofAmerican Journal of Clinical Nutrition
dc.sourceWeb of Science
dc.titleSite-specific concentrations of carotenoids in adipose tissue: relations with dietary and serum carotenoid concentrations in healthy adultsen
dcterms.rightsHolderAmer Soc Clinical Nutrition
dc.contributor.institutionTufts Univ
dc.contributor.institutionYonsei Univ
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionNortheastern University
dc.description.affiliationTufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Boston, MA 02111 USA
dc.description.affiliationYonsei Univ, Seoul 120749, South Korea
dc.description.affiliationUNESP, Fac Med Botucatu, Botucatu, SP, Brazil
dc.description.affiliationNortheastern Univ, Bouve Coll Hlth Sci, Boston, MA 02115 USA
dc.description.affiliationUnespUNESP, Fac Med Botucatu, Botucatu, SP, Brazil
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dc.description.sponsorshipIdUS Department of Agriculture: 58-1950-9-001
dc.description.sponsorshipIdFAPESP: 97/2502-9
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
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