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dc.contributor.authorCastellar, A. [UNESP]
dc.contributor.authorRemedio, R. N. [UNESP]
dc.contributor.authorBarbosa, R. A. [UNESP]
dc.contributor.authorGomes, R. J.
dc.contributor.authorCaetano, Flávio Henrique [UNESP]
dc.date.accessioned2014-05-20T15:34:23Z
dc.date.available2014-05-20T15:34:23Z
dc.date.issued2011-02-01
dc.identifierhttp://dx.doi.org/10.1016/j.tice.2010.11.001
dc.identifier.citationTissue & Cell. Edinburgh: Churchill Livingstone, v. 43, n. 1, p. 24-28, 2011.
dc.identifier.issn0040-8166
dc.identifier.urihttp://hdl.handle.net/11449/42530
dc.description.abstractDiabetic cardiomyopathy contributes to the high incidence of mortality in both types of diabetes. We aimed to investigate the histochemical aspects of collagen and reticular fibers in the cardiac muscle and evaluate the influence of physical exercise on these aspects. Wistar rats were divided in 4 groups: sedentary control (SC), trained control (TC), sedentary diabetic (SD) and trained diabetic (TD). Diabetes was induced with alloxan (35 mg/kg). Training program consisted of swimming 1 h/day with a load of 4.8% of body weight for TD and 5.2% for TC. during 8 weeks. At the end of the experiment, samples of the left ventricle were collected, fixed in Bouin and processed on historesin. Sections were stained with periodic acid of Schiff, picrosirius-hematoxylin and ammoniacal silver. The PAS technique shows that individuals of group SD presented more intense reaction that the other groups. Picrosirius-hematoxylin technique showed a possible deposition of collagen fibers in SD. The TD group presented a reaction a lot similar to the controls' for both techniques', showing a possible prevention of this deposition. These results indicate that physical exercises might have an important role on the prevention of some negative alterations caused by experimental diabetes. (C) 2010 Elsevier Ltd. All rights reserved.en
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent24-28
dc.language.isoeng
dc.publisherChurchill Livingstone
dc.relation.ispartofTissue & Cell
dc.sourceWeb of Science
dc.subjectDiabetes mellitusen
dc.subjectMyocardiumen
dc.subjectExerciseen
dc.subjectHistochemistryen
dc.subjectAlloxanen
dc.titleCollagen and reticular fibers in left ventricular muscle in diabetic rats: Physical exercise prevents its changes?en
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderChurchill Livingstone
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationSão Paulo State Univ, Dept Biol, São Paulo, Brazil
dc.description.affiliationUniv Fed São Paulo, Dept Biosci, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Dept Biol, São Paulo, Brazil
dc.identifier.doi10.1016/j.tice.2010.11.001
dc.identifier.wosWOS:000288637500003
dc.rights.accessRightsAcesso aberto
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Rio Claropt
dc.identifier.fileWOS000288637500003.pdf
dc.identifier.lattes4396826019535898
unesp.author.lattes4396826019535898
unesp.author.orcid0000-0002-9913-8565[2]
dc.relation.ispartofjcr1.438
dc.relation.ispartofsjr0,410
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