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dc.contributor.authorAntoniazzi, Marta M.
dc.contributor.authorBenvenuti, Luiz A.
dc.contributor.authorLira, Marcela S.
dc.contributor.authorJared, Simone G. S.
dc.contributor.authorGarrone Neto, Domingos [UNESP]
dc.contributor.authorJared, Carlos
dc.contributor.authorBarbaro, Katia C.
dc.date.accessioned2014-05-20T15:34:35Z
dc.date.available2014-05-20T15:34:35Z
dc.date.issued2011-02-01
dc.identifierhttp://dx.doi.org/10.1016/j.toxicon.2010.12.005
dc.identifier.citationToxicon. Oxford: Pergamon-Elsevier B.V. Ltd, v. 57, n. 2, p. 297-303, 2011.
dc.identifier.issn0041-0101
dc.identifier.urihttp://hdl.handle.net/11449/42590
dc.description.abstractPain is the most conspicuous symptom observed in patients wounded by stingrays, and skin necrosis is common in accidents by freshwater stingrays. The extract from the stinger integumentary tissue of Potamotrygon falkneri containing toxic components (venom) was tested for its ability to induce histopathological changes in the dorsal skin of mice at different times. 3-6 h after injection, foci of necrosis in isolated basal epidermal cells were observed. Full coagulative necrosis of the skin, subcutaneous tissue and skeletal muscle was evident as soon as 24 h after venom exposure, with a clear demarcation from the normal skin. After 48 h, round collections of necrotic cells start to coalesce originating extensive skin necrotic plaques that detach from viable tissue after 72-96 h. Inflammatory infiltrate was observed after 6 h, but was always mild. Acute vascular thrombosis was rare, and hemorrhage was not present at any time. Superficial bacterial infection was present in two of the examined cases. In conclusion, the venom of P. falkneri is responsible for the development of an early necrosis with mild inflammatory reaction, probably due to direct action of the venom. The severe local damage is probably worsened by the mechanical trauma caused by the stinger. (c) 2010 Elsevier Ltd. All rights reserved.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent297-303
dc.language.isoeng
dc.publisherPergamon-Elsevier B.V. Ltd
dc.relation.ispartofToxicon
dc.sourceWeb of Science
dc.subjectStingraysen
dc.subjectPotamotrygonen
dc.subjectVenomen
dc.subjectToxinen
dc.subjectDermonecrosisen
dc.subjectHistopathologyen
dc.titleHistopathological changes induced by extracts from the tissue covering the stingers of Potamotrygon falkneri freshwater stingraysen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderPergamon-Elsevier B.V. Ltd
dc.contributor.institutionInstituto Butantan
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.description.affiliationInst Butantan, Lab Imunopatol, BR-05503900 São Paulo, Brazil
dc.description.affiliationInst Butantan, Lab Biol Celular, BR-05503900 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Inst Coracao InCor, Fac Med, BR-05403000 São Paulo, Brazil
dc.description.affiliationBrazil UNESP, Inst Biociencias, UNESP, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespBrazil UNESP, Inst Biociencias, UNESP, BR-18618000 Botucatu, SP, Brazil
dc.identifier.doi10.1016/j.toxicon.2010.12.005
dc.identifier.wosWOS:000287629400013
dc.rights.accessRightsAcesso aberto
dc.description.sponsorshipIdFAPESP: 07/55272-4
dc.description.sponsorshipIdCNPq: 304800/2007-4
dc.description.sponsorshipIdCNPq: 142985/2005-8
dc.description.sponsorshipIdCNPq: 307029/2009-3
dc.description.sponsorshipIdCNPq: 307247/2007-4
dc.identifier.fileWOS000287629400013.pdf
unesp.author.orcid0000-0002-9117-6276[6]
dc.relation.ispartofjcr2.352
dc.relation.ispartofsjr0,692
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