Mandibular cortical bone evaluation on cone beam computed tomography images of patients with bisphosphonate-related osteonecrosis of the jaw
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2012-05-01
Autores
Torres, Sandra R.
Chen, Curtis S. K.
Leroux, Brian G.
Lee, Peggy P.
Hollender, Lars G.
Santos, Eduardo C. A. [UNESP]
Drew, Shane P.
Hung, Kuei-Ching
Schubert, Mark M.
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Elsevier B.V.
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Objectives. The objective of this study was to develop a technique for detecting cortical bone dimensional changes in patients with bisphosphonate-related osteonecrosis of the jaw (BRONJ).Study Design. Subjects with BRONJ who had cone-beam computed tomography imaging were selected, with age- and gender-matched controls. Mandibular cortical bone measurements to detect bisphosphonate-related cortical bone changes were made inferior to mental foramen, in 3 different ways: within a fixed sized rectangle, in a rectangle varying with the cortical height, and a ratio between area and height.Results. Twelve BRONJ cases and 66 controls were evaluated. The cortical bone measurements were significantly higher in cases than controls for all 3 techniques. The bone measurements were strongly associated with BRONJ case status (odds ratio 3.36-7.84). The inter-rater reliability coefficients were high for all techniques (0.71-0.90).Conclusions. Mandibular cortical bone measurement is a potentially useful tool in the detection of bone dimensional changes caused by bisphosphonates. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;113:695-703)
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Oral Surgery Oral Medicine Oral Pathology Oral Radiology. New York: Elsevier B.V., v. 113, n. 5, p. 695-703, 2012.