Infection and apparent invasion of Vero cells by Paracoccidioides brasiliensis

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Data

1994-01-01

Autores

Mendes-Giannini, Maria José Soares [UNESP]
Ricci, L. C. [UNESP]
Uemura, M. A. [UNESP]
Toscano, E. [UNESP]
Arns, C. W. [UNESP]

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Resumo

Paracoccidioides brasiliensis probably uses many different mechanisms to establish itself in the host and cause disease. In this work, we assess an in vitro model system which uses cultured mammalian cells to investigate the virulence factors of P. brasiliensis. We were able to demonstrate an invasion process of the yeast form of this fungus in Vero cell cultures. We deduced that the overall invasive process involved three steps: adhesion, followed by invasion of individual epithelial cells and spread to adjacent cells.

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Palavras-chave

Cell culture, Epithelium cell, Fungus, Immunofluorescence, Immunoperoxidase staining, Nonhuman, Paracoccidioides brasiliensis, South american blastomycosis, Vero cell, Animal, Cell Adhesion, Cercopithecus aethiops, Models, Biological, Paracoccidioides, Paracoccidioidomycosis, Support, Non-U.S. Gov't, Time Factors, Vero Cells

Como citar

Journal of Medical and Veterinary Mycology, v. 32, n. 3, p. 189-197, 1994.