Effects of protein malnutrition on glucose tolerance in rats with alloxan-induced diabetes
MetadataShow full item record
Protein-calorie malnutrition produces glucose intolerance and reduced insulin release in response to glucose. Rats adapted to low- or high-protein diets show an increased resistance to the diabetogenic action of a single dose of streptozotocin or alloxan. To determine the effects of dietary protein level on pancreatic function, we measured serum glucose levels under basal conditions and during the oral glucose tolerance test (GTT) performed before and after a single dose of alloxan administered to rats fed a 25% or a 6% protein diet for a period of 8 weeks. The incidence of mild hyperglycemia (serum glucose > 250 mg/dl) was greater among the rats fed the 25% protein diet (81%) than among those fed the 6% protein diet (42%). During the GTT performed before alloxan administration the serum glucose levels of the rats fed the 6% protein diet were not found to be significantly different from those of rats fed the 25% protein diet. During the GTT performed after alloxan injection all rats showed intolerance to the substrate (serum glucose > 160 mg/dl 120 min after glucose administration) regardless of whether basal serum glucose was normal or high. In summary, alloxan was less effective in producing basal hyperglycemia in the rats fed the 6% protein diet than in those fed the 25% protein diet but caused glucose intolerance during the oral GTT in both groups. Thus, it seems that feeding a 6% protein diet to rats offers only partial protection against the toxic effects of alloxan.
How to cite this document
Showing items related by title, author, creator and subject.
Heat shock protein production and immunity and altered fetal development in diabetic pregnant rats Saito, Felipe Hiroshi ; Damasceno, Débora Cristina ; Dallaqua, Bruna ; Linhares, Iara Moreno; Rudge, Marilza Vieira Cunha ; De Mattos Paranhos Calderon, Iracema ; Witkin, Steven Sol (Cell Stress and Chaperones, 2013) [Artigo]We evaluated associations between the concentrations of heat shock proteins (hsp60 and hsp70) and their respective antibodies, alterations in maternal reproductive performance, and fetal malformations in pregnant rats with ...
Pancreatic β-cell defects in women at risk of type 2 diabetes Pimenta, W. P. ; Rudge, Marilza Vieira Cunha ; Aragon, F. F. ; Padovani, Carlos Roberto (Diabetes Research and Clinical Practice, 2004) [Artigo]We evaluated insulin release and insulin sensitivity in women with basal and/or postprandial hyperglycemia but normal oral glucose tolerance test (OGTT) in previous pregnancy (GHG). These women were individually matched ...
Acute and short-term insulin-induced molecular adaptations of GLUT2 gene expression in the renal cortex of diabetic rats Freitas, Helayne Soares; D'Agord Schaan, Beatriz; Seraphim, Patricia Monteiro; Nunes, Maria Tereza; Machado, Ubiratan Fabres (Molecular and Cellular Endocrinology, 2005) [Artigo]Increased GLUT2 gene expression in the renal proximal tubule of diabetic rats is an adaptive condition, which may be important in the diabetic nephropathy development. We investigated the effects of insulin treatment upon ...