Influencia da elevacao sustentada da pressao arterial sobre a dP/dt do ventriculo esquerdo mantendo-se constante a pressao diastolica do ventriculo esquerdo
Alternative titleInfluence of sustained elevations of arterial pressure on the left ventricular dP/dt keeping constant the left ventricular end diastolic pressure
MetadataShow full item record
Purpose - To evaluate the influence of sustained elevations of arterial pressure on dP/dt values, which the left ventricular end diastolic pressure was kept constant. Methods - Thirteen anesthetized dogs, mechanically ventilated and submitted to thoracotomy and pharmacological autonomic block (atropine - 0.5 mg/kg IV + oxprenolol - 3 mg/kg IV) were studied. The arterial pressure elevation was obtained by mechanical constriction of the descending thoracic aorta. Analyses were made in control (C) situation and after two successives increments of arterial pressure, sustained for 10min, called hypertension 1 (H1) and hypertension 2 (H2), respectively. The end diastolic left ventricular pressure was kept constant by utilization of a perfusion system connected to the left atria. Results - Heart rate did not change (C: 125 ± 13.9bpm; H1: 125 ± 13.5bpm; H2: 123 ± 14.1bpm; p > 0.05); the LVSP increased (C: 119 ± 8.1mmHg; H1: 142 ± 7.9mmHg; H2: 166 ± 7.7mmHg; p < 0.01); the AoDP increased (C: 89 ± 11.6mmHg; H1: 99 ± 9.5mmHg; H2: 120 ± 11.8mmHg; p < 0.01); the LVEDP (C: 6.2 ± 2.48mmHg; H1: 6.3 ± 2.43mmHg; H2: 6.1 ± 2.51mmHg; p > 0.05) and the dP/dt (C: 3068 ± 1057.1mmHg/s; 3112 ± 995.7mmHg/s; H2: 3086 ± 979.5mmHg/s; p > 0.05) did not change. Conclusion - dP/dt values are not influenced by a sustained elevation of arterial pressure, when the end diastolic left ventricular pressure is kept constant.
How to cite this document
Showing items related by title, author, creator and subject.
Soriano, Eline A. ; Gaiolla, Paula Schmidt Azevedo ; Miot, Hélio Amante ; Minicucci, Marcos Ferreira ; Pansani, Mariele C. ; Matsubara, Luiz Shiguero ; Okoshi, Katashi ; Zornoff, Leonardo Antonio Mamede ; Matsubara, Beatriz Bojikian ; Paiva, Sergio A.R. (International Journal of Cardiology, 2013) [Artigo]Background: Currently, 13-cis-retinoic acid (13-cis-RA) is the most effective therapy for acne. Isotretinoin, a first-generation synthetic 13-cis-RA compound, is associated with numerous adverse effects. To investigate the ...
Damatto, R. L. ; Martinez, P. F. ; Lima, A. R R ; Cezar, M. D M ; Campos, D. H S ; Oliveira Junior, S. A. ; Guizoni, D. M. ; Bonomo, C. ; Nakatani, B. T. ; Dal Pai Silva, M. et al. (International Journal of Cardiology, 2013) [Artigo]Background: Although skeletal muscle atrophy and changes in myosin heavy chain (MyHC) isoforms have often been observed during heart failure, their pathophysiological mechanisms are not completely defined. In this study ...
Waist circumference, but not body mass index, is a predictor of ventricular remodeling after anterior myocardial infarction Cogni, Ana Lucia ; Farah, Elaine ; Minicucci, Marcos Ferreira ; Gaiolla, Paula Schmidt Azevedo ; Okoshi, Katashi ; Matsubara, Beatriz Bojikian ; Zanati, Silméia G. ; Paiva, Sergio A.R. ; Zornoff, Leonardo Antonio Mamede (Nutrition, 2013) [Artigo]Objective: The impact of obesity on ventricular remodeling after myocardial infarction (MI) is still poorly understood. Therefore, the aim of this study was to evaluate the role of waist circumference (WC) and body mass ...