Assessment of vitamin A status in chronic obstructive pulmonary disease patients and healthy smokers
MetadataShow full item record
The relation between vitamin A status and the degree of lung airway obstruction was examined in a cross-sectional study of 36 male subjects aged 43-74 y who were assigned to five groups as follows: healthy nonsmokers (n = 7), healthy smokers (n = 7), mild chronic obstructive pulmonary disease (COPD-mild) patients (n = 9), COPD-moderate-severe patients (n = 7), and COPD-moderate-severe patients with exacerbation (+ex; n = 6). Smoking habits, pulmonary function tests, and energy-protein status were assessed; serum concentrations of retinyl esters, retinol, retinol binding protein, and transthyretin and relative dose responses were measured. In addition, 12 male smokers aged 45-61 y with mild COPD were randomly assigned to two groups for a longitudinal study: six subjects consumed vitamin A (1000 RE/d; COPD- vitamin A) and six subjects received placebo for 30 d. Lowered serum retinol concentrations were found in the COPD-moderate-severe and COPD-moderate- severe+ex groups. Measurements of vitamin A status in healthy smokers and in COPD-mild patients were not different from those in healthy nonsmokers. The improvement of pulmonary function test results after vitamin A supplementation [mean increase for 1-s forced expiratory volume (FEV1) = 22.9% in the COPD-vitamin A group] may support the assumption of a local (respiratory) vitamin A deficiency in patients with this disease.
How to cite this document
Showing items related by title, author, creator and subject.
Paiva, Sergio Alberto Rupp de ; Russell, Robert M.; Dutta, Sudhir K. (Journal of the American College of Nutrition, 1999) [Resenha]Carotenoids are natural pigments which are synthesized by plants and are responsible for the bright colors of various fruits and vegetables. There are several dozen carotenoids in the foods that we eat, and most of these ...
Avaliação do retinol no escarro e no soro de tabagistas e pacientes com doença pulmonar obstrutiva crônica e sua relação com o processo inflamatório Amaral, Renata Antonialli Ferreira do (Universidade Estadual Paulista (UNESP), 2010) [Dissertação de mestrado]A doença pulmonar obstrutiva crônica (DPOC) e o tabagismo são doenças inflamatórias que interferem no metabolismo da vitamina A; entretanto, o comportamento do retinol nas vias aéreas destes pacientes ainda é desconhecido. ...
Plasma levels of transthyretin and retinol-binding protein in child-a cirrhotic patients in relation to protein-calorie status and plasma amino acids, zinc, vitamin a and plasma thyroid hormones Calamita, Zamir; Dichi, Isaías; Papini-Berto, Sílvia J.; Dichi, Jane B.; Angeleli, Aparecida Y.O.; Vannucchi, Hélio; Caramori, Carlos Antonio ; Burini, Roberto Carlos (Arquivos de Gastroenterologia, 1997) [Artigo]Transthyretin and retinal-binding protein are sensitive markers of acute protein-calorie malnutrition both for early diagnosis and dietary evaluation. A preliminary study showed that retinal-binding protein is the most ...