Isolation of ergosterol peroxide and its reversion to ergosterol in the pathogenic fungus Sporothrix schenckii
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Data
1997-12-01
Autores
Da Graça Sgarbi, Diana Bridon
Da Silva, Antonio Jorge Ribeiro
Carlos, Iracilda Zeppone [UNESP]
Silva, Célio Lopes
Angluster, Jayme
Alviano, Celuta Sales
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Resumo
Ergosterol peroxide, a presumed product of the H2O2-dependent enzymatic oxidation of ergosterol, has been isolated from yeast from yeast forms of the pathogenic fungus Sporothrix schenckii. The substance, which may have a role in fungal virulence, has been characterized mainly using spectroscopic methods (1H and 13C nuclear magnetic resonance and high resolution mass spectra). The purified compound showed a molecular formula of C28H44O3, displaying characteristic features of epidioxy sterols and was reverted to ergosterol when submitted to S. schenckii enzymatic extract.
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Epidioxy sterol, Reactive oxygen species, Sporothrix schenckii, antineoplastic agent, drug derivative, ergosterol, ergosterol 5,8 peroxide, ergosterol-5,8-peroxide, chemistry, isolation and purification, metabolism, nuclear magnetic resonance spectroscopy, Sporothrix, thin layer chromatography, Antineoplastic Agents, Chromatography, Thin Layer, Ergosterol, Magnetic Resonance Spectroscopy, Fungi
Como citar
Mycopathologia, v. 139, n. 1, p. 9-14, 1997.