Show simple item record

dc.contributor.authorGonzalez, Fabiana G. [UNESP]
dc.contributor.authorDi Stasi, Luiz C. [UNESP]
dc.date.accessioned2014-05-27T11:20:27Z
dc.date.available2014-05-27T11:20:27Z
dc.date.issued2002-04-22
dc.identifierhttp://dx.doi.org/10.1078/0944-7113-00096
dc.identifier.citationPhytomedicine, v. 9, n. 2, p. 125-134, 2002.
dc.identifier.issn0944-7113
dc.identifier.urihttp://hdl.handle.net/11449/66874
dc.description.abstractWilbrandia ebracteata (Cogn.) Cogn. is a medicinal plant belonging to the Cucurbitaceae family used popularly as an antiulcer and analgesic medicine. The hydromethanol extract of leaves was investigated to determine its anti-ulcerogenic (ethanol and indomethacin induced gastric damage) and analgesic (writhing and tail-flick tests) activities in mice (efficacy), its acute toxicity (safety), and its phytochemistry (quality control). Oral administration of leaf extract at a dose of 1000 mg/kg body wt. significantly reduced 73.3% of the total area of lesion in ethanol-induced gastric damage, but was inactive in an indomethacin-induced gastric damage test. The hydromethanol extract was also inactive in both analgesic tests. Oral administration of the leaf extract did not produce mortality in mice, while the LD50 value of the roots was 22.10 mg/kg body wt. in female mice and 58.31 mg/kg body wt. in male mice. Leaves of W. ebracteata reacted positively for steroids, flavonols, flavanones, saponins, tannins and xanthones and negative for other compounds, including cucurbitacins. Leaf extract of W. ebracteata was active as an anti-ulcerogenic, probably through increasing gastric defensive factors, and flavonoids might be the main constituent responsible for this activity.en
dc.format.extent125-134
dc.language.isoeng
dc.relation.ispartofPhytomedicine
dc.sourceScopus
dc.subjectAnalgesic
dc.subjectAnti-ulcerogenic
dc.subjectCucurbitaceae
dc.subjectFlavonoids
dc.subjectMedicinal plants
dc.subjectWilbrandia ebracteata
dc.subjectanalgesic agent
dc.subjectantiulcer agent
dc.subjectflavanone derivative
dc.subjectflavonoid
dc.subjectflavonol derivative
dc.subjectindometacin
dc.subjectmethanol derivative
dc.subjectplant extract
dc.subjectsaponin derivative
dc.subjectsteroid
dc.subjecttannin derivative
dc.subjectunclassified drug
dc.subjectWilbrandia ebracteata extract
dc.subjectxanthone derivative
dc.subjectanalgesic activity
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectcontrolled study
dc.subjectdrug efficacy
dc.subjectdrug safety
dc.subjectLD 50
dc.subjectmale
dc.subjectmedicinal plant
dc.subjectmouse
dc.subjectnonhuman
dc.subjectphytochemistry
dc.subjectplant leaf
dc.subjectplant root
dc.subjectpriority journal
dc.subjectstomach injury
dc.subjecttail flick test
dc.subjectwrithing test
dc.subjectAcute Toxicity Tests
dc.subjectAnalgesics
dc.subjectAnalgesics, Opioid
dc.subjectAnimals
dc.subjectAnti-Inflammatory Agents, Non-Steroidal
dc.subjectAnti-Ulcer Agents
dc.subjectAspirin
dc.subjectBrazil
dc.subjectCimetidine
dc.subjectEthanol
dc.subjectFemale
dc.subjectGastric Mucosa
dc.subjectIndomethacin
dc.subjectMale
dc.subjectMice
dc.subjectMorphine
dc.subjectMotor Activity
dc.subjectOmeprazole
dc.subjectPhytotherapy
dc.subjectPlant Extracts
dc.subjectRats
dc.subjectStomach Ulcer
dc.subjectTail
dc.subjectAnimalia
dc.titleAnti-ulcerogenic and analgesic activities of the leaves of Wilbrandia ebracteata in miceen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationLaboratory of Phytomedicines Department of Pharmacology Universidade Estadual Paulista (UNESP)
dc.description.affiliationUnespLaboratory of Phytomedicines Department of Pharmacology Universidade Estadual Paulista (UNESP)
dc.identifier.doi10.1078/0944-7113-00096
dc.identifier.wosWOS:000175437900006
dc.rights.accessRightsAcesso restrito
dc.identifier.scopus2-s2.0-0036214385
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.author.orcid0000-0002-5074-0539[1283]
unesp.author.orcid0000-0002-0429-2448[429]
unesp.author.orcid0000-0002-7088-8557[964]
unesp.author.orcid0000-0003-0217-7021[1092]
unesp.author.orcid0000-0002-9746-4594[2047]
unesp.author.orcid0000-0003-0409-0341[2071]
unesp.author.orcid0000-0002-9540-5742[1083]
unesp.author.orcid0000-0003-2461-275X[737]
unesp.author.orcid0000-0002-5213-3708[1096]
unesp.author.orcid0000-0002-2363-8889[717]
unesp.author.orcid0000-0002-2978-2718[215]
unesp.author.orcid0000-0003-0505-4908[1560]
unesp.author.orcid0000-0002-4184-9380[1499]
unesp.author.orcid0000-0001-8809-8927[1078]
unesp.author.orcid0000-0001-6998-1108[139]
unesp.author.orcid0000-0002-1255-2211[745]
unesp.author.orcid0000-0002-3769-1680[128]
unesp.author.orcid0000-0002-0782-0883[734]
unesp.author.orcid0000-0001-5732-7950[93]
unesp.author.orcid0000-0002-2633-6712[1131]
unesp.author.orcid0000-0002-7531
dc.relation.ispartofjcr3.610
dc.relation.ispartofsjr1,087
Localize o texto completo

Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record