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dc.contributor.authorAlves de Lima, R. O. [UNESP]
dc.contributor.authorAzevedo, L.
dc.contributor.authorRibeiro, Lúcia Regina [UNESP]
dc.contributor.authorSalvadori, Daisy Maria Favero [UNESP]
dc.date.accessioned2014-05-27T11:20:36Z
dc.date.available2014-05-27T11:20:36Z
dc.date.issued2003-02-01
dc.identifierhttp://dx.doi.org/10.1016/S0278-6915(02)00208-9
dc.identifier.citationFood and Chemical Toxicology, v. 41, n. 2, p. 189-192, 2003.
dc.identifier.issn0278-6915
dc.identifier.urihttp://hdl.handle.net/11449/67182
dc.description.abstractMost manufactured foods contain chemicals added as a deliberate part of the manufacturing process. The aims of the present study were to evaluate the mutagenicity and antimutagenicity of annatto, a natural pigment extracted from the Bixa orellana L. and widely used as a colorant in foods. The micronucleus test was performed in bone marrow cells from Swiss male mice treated with one of the three concentrations of annatto (1330, 5330 and 10,670 ppm), incorporated into the diet. The animals were fed with the diets for 7 days and sacrificed 24 h after the last treatment. For the evaluation of the antimutagenic potential of annatto, at day 7, the animals received an intraperitoneal injection of cyclophosphamide (50 mg/kg body weight). Under the concentrations tested annatto did not present mutagenic or antimutagenic activities on the mice bone marrow cells. However, an increased frequency of micronucleated cells was observed when the highest concentration (10,670 ppm) was administered simultaneously with cyclophosphamide. In conclusion, the data indicate that annatto colour, for the conditions used, is neither mutagenic nor an inhibitor of induced mutations, although it should be used carefully since high doses may increase the effect of a mutagen. © 2003 Elsevier Science Ltd. All rights reserved.en
dc.format.extent189-192
dc.language.isoeng
dc.relation.ispartofFood and Chemical Toxicology
dc.sourceScopus
dc.subjectAnnatto
dc.subjectAntimutagenicity
dc.subjectBixa orellana L.
dc.subjectMicronucleus
dc.subjectMutagenicity
dc.subjectNatural food colours
dc.subjectannato
dc.subjectantimutagenic agent
dc.subjectbixa orellana extract
dc.subjectcyclophosphamide
dc.subjectfood dye
dc.subjectmutagenic agent
dc.subjectplant extract
dc.subjectunclassified drug
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal food
dc.subjectanimal model
dc.subjectbixa orellana
dc.subjectbone marrow cell
dc.subjectcontrolled study
dc.subjectdiet
dc.subjectmale
dc.subjectmicronucleus test
dc.subjectmouse
dc.subjectmutagenicity
dc.subjectmutation
dc.subjectnonhuman
dc.subjectplant
dc.subjectAdministration, Oral
dc.subjectAnimals
dc.subjectAntimutagenic Agents
dc.subjectBixaceae
dc.subjectBone Marrow Cells
dc.subjectCarotenoids
dc.subjectCyclophosphamide
dc.subjectDiet
dc.subjectDose-Response Relationship, Drug
dc.subjectDrug Synergism
dc.subjectFood Coloring Agents
dc.subjectInjections, Intraperitoneal
dc.subjectMale
dc.subjectMice
dc.subjectMicronucleus Tests
dc.subjectMutagens
dc.subjectPlant Extracts
dc.subjectAnimalia
dc.subjectBixa orellana
dc.titleStudy on the mutagenicity and antimutagenicity of a natural food colour (annatto) in mouse bone marrow cellsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionCurso de Nutrição
dc.contributor.institutionUniversidade Luterana do Brasil
dc.description.affiliationTOXICAN - Nuc. Aval. Toxic./Cancer. Depto. de Patologia Faculdade de Medicina- UNESP, Botucatu, SP
dc.description.affiliationFaculdade de Medicina de Itajuba Curso de Nutrição, Itajubá, MG
dc.description.affiliationUniversidade Luterana do Brasil, Canoas, RS
dc.description.affiliationUnespTOXICAN - Nuc. Aval. Toxic./Cancer. Depto. de Patologia Faculdade de Medicina- UNESP, Botucatu, SP
dc.identifier.doi10.1016/S0278-6915(02)00208-9
dc.identifier.wosWOS:000180425600002
dc.rights.accessRightsAcesso restrito
dc.identifier.scopus2-s2.0-18744396655
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
dc.identifier.lattes5051118752980903
unesp.author.lattes5051118752980903
unesp.author.orcid0000-0001-9323-3134[4]
unesp.author.orcid0000-0002-0502-4090[2]
dc.relation.ispartofjcr3.977
dc.relation.ispartofsjr1,144
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