Behavioural alterations provoked by prolonged calcitonin administration in rats
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Data
2003-07-01
Autores
Arone, Ana Elisa F. [UNESP]
De Aguiar, Daniele Cristina [UNESP]
Godinho, Antônio Francisco [UNESP]
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Resumo
Present work investigated the effect of prolonged administration of salmon calcitonin, a hormone secreted by parafollicular cells from thyroid, on behavioural parameters of rats. Animals received calcitonin sc, 100 mUI/100 g of body weight, three times a week, during 50 days. Behaviour was assessed utilizing an Open Field, Elevated Plus-Maze and Hole Board apparatus. Calcitonin treatment in rats seems to modify open field and elevated plus maze behaviour, suggesting emotionality and anxiety state alterations of the animals. These conditions can be provoked due to the direct calcitonin action on its receptors, even though we do not exclude an action mediated by tissue calcium level alterations.
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Behavior, Calcitonin, Elevated-Plus-Maze, Hole Board, Open Field, Rat, calcitonin, animal behavior, animal experiment, behavior, controlled study, emotionality, male, maze test, nonhuman, open field behavior, rat, thyroid gland, thyroid parafollicular cell, tissue level, Animalia
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Revista Brasileira de Toxicologia, v. 16, n. 1, p. 5-9, 2003.