Dietary restriction and fibre supplementation: Oxidative stress and metabolic shifting for cardiac health
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Data
2003-11-01
Autores
Diniz, Yeda S. [UNESP]
Cicogna, Antonio C. [UNESP]
Padovani, Carlos R. [UNESP]
Silva, Maeli D. P. [UNESP]
Faine, Luciane A. [UNESP]
Galhardi, Cristiano M.
Rodrigues, Hosana G.
Novelli, Ethel L. B.
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Resumo
Dietary modification ought to be the first line of strategy in prevention of the development of cardiac disease. The purpose of this study was to investigate whether dietary restriction, dietary-fibre-enriched diet, and their interactions might affect antioxidant capacity and oxidative stress in cardiac tissue. Male Wistar rats (180-200 g; n = 10) were divided into four groups: control ad libitum diet (C), 50% restricted diet (DR), fed with fibre-enriched diet (F), and 50% restricted fibre-enriched diet (DR-F). After 35 days of the treatments, F, DR, and DR-F rats showed low cholesterol, LDL-cholesterol, and triacylglycerol, and high HDL-cholesterol in serum. The DR, DR-F, and F groups had decreased myocardial lipoperoxide and lipid hydroperoxide. The DR-F and F treatments increased superoxide dismutase and glutatione peroxidase (GSH-Px). The DR treatment increased GSH-Px and catalase activities. Dietary fibre beneficial effects were related to metabolic alterations. The F and DR-F groups showed high cardiac glycogen and low lactate dehydrogenase/citrate synthase ratios, indicating diminished anaerobic and elevated aerobic myocardial metabolism in these animals. There was no synergistic effect between dietary restriction and dietary fibre addition, since no differences were observed in markers of oxidative stress in the F and DR-F groups. Dietary fibre supplementation, rather than energy intake and dietary restriction, appears to be the main process retarding oxidative stress in cardiac tissue.
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Palavras-chave
Cardiac tissue, Dietary fibre, Dietary restriction, Oxidative stress, biological marker, catalase, cholesterol, citrate synthase, glutathione peroxidase, glycogen, high density lipoprotein cholesterol, lactate dehydrogenase, lipid hydroperoxide, lipid peroxide, low density lipoprotein cholesterol, superoxide dismutase, triacylglycerol, aerobic metabolism, animal experiment, animal model, animal tissue, cholesterol blood level, controlled study, diet restriction, diet supplementation, enzyme activity, heart, heart disease, heart muscle metabolism, male, nonhuman, oxidative stress, priority journal, rat, triacylglycerol blood level, Animals, Antioxidants, Caloric Restriction, Dietary Fiber, Male, Myocardium, Oxidative Stress, Rats, Rats, Wistar
Como citar
Canadian Journal of Physiology and Pharmacology, v. 81, n. 11, p. 1042-1048, 2003.