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dc.contributor.authorScarano, W. R.
dc.contributor.authorCordeiro, R. S.
dc.contributor.authorGóes, R. M. [UNESP]
dc.contributor.authorTaboga, S. R. [UNESP]
dc.date.accessioned2014-05-27T11:21:04Z
dc.date.available2014-05-27T11:21:04Z
dc.date.issued2004-04-01
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/15554500
dc.identifier.citationJournal of Submicroscopic Cytology and Pathology, v. 36, n. 2, p. 141-148, 2004.
dc.identifier.issn1122-9497
dc.identifier.urihttp://hdl.handle.net/11449/67704
dc.description.abstractThe prostate is an accessory gland of the mammal reproductive system with great volume and high functional importance. Many works infer that, in addition to the androgenic ones, the estrogen can be associated with benign prostatic hyperplasia and prostatic cancer, but no conclusive evidence exists on the role of estrogen in normal prostatic and neoplastic tissue. The objective of this work was to evaluate the effects of chronic administration of estradiol benzoate on the lateral prostate of guinea pigs in the pre-pubescent, pubescent, post-pubescent and adult phases, with emphasis on the modifications provoked by this hormone on the glandular epithelium. The analyses of the estradiol-treated and control groups were investigated using histological procedures and transmission electron microscopy. The histopathological analysis of the lateral prostate in the treated group revealed areas where epithelial dysplasia was observed, assuming at some places a pattern of epithelial stratification characteristic of prostatic intraepithelial neoplasia. After ultrastructural analysis, the following were observed: enlargement of the internal membranes, heterogeneity in the cellular types, hypertrophy of the basal cells and apparent decrease of cytoplasmic organelles in some cells of the prostatic intraepithelial neoplasia. Still, a loss of cellular polarity was observed, along with nuclei of various forms, sizes and heights - as well as irregular chromatin distribution patterns. Such alterations were found mainly in pubescent, post-pubescent and adult animals subject to the chronic administration of estradiol. These findings reinforce the already existent data in understanding the role of estrogen in the etiology of prostatic diseases.en
dc.format.extent141-148
dc.language.isoeng
dc.relation.ispartofJournal of Submicroscopic Cytology and Pathology
dc.sourceScopus
dc.subjectEpithelium
dc.subjectEstradiol
dc.subjectGuinea pig
dc.subjectHyperplasia
dc.subjectProstate
dc.subjectestradiol
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectcell type
dc.subjectchromatin
dc.subjectcontrolled study
dc.subjectdevelopmental stage
dc.subjectguinea pig
dc.subjecthistology
dc.subjecthistopathology
dc.subjectnonhuman
dc.subjectprostate epithelium
dc.subjecttransmission electron microscopy
dc.subjectAging
dc.subjectAnimals
dc.subjectAnimals, Newborn
dc.subjectEpithelial Cells
dc.subjectGuinea Pigs
dc.subjectMale
dc.subjectMicroscopy, Electron, Transmission
dc.subjectProstatic Intraepithelial Neoplasia
dc.subjectProstatic Neoplasms
dc.subjectSexual Maturation
dc.subjectAnimalia
dc.subjectCavia
dc.subjectCavia porcellus
dc.subjectMammalia
dc.subjectSus scrofa
dc.titleIntraepithelial alterations in the Guinea pig lateral prostate at different ages after estradiol treatmenten
dc.typeArtigo
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationDepartment of Cell Biology UNICAMP, Campinas, São Paulo
dc.description.affiliationMicrosc. and Microanalysis Lab. Department of Biology UNESP, S. Jose do Rio Preto, S. Paulo
dc.description.affiliationDepartamento de Biologia IBILCE -UNESP, R. Cristovao Colombo, 2265, S. Jose Rio Preto, SP, CEP 15054-000
dc.description.affiliationUnespMicrosc. and Microanalysis Lab. Department of Biology UNESP, S. Jose do Rio Preto, S. Paulo
dc.description.affiliationUnespDepartamento de Biologia IBILCE -UNESP, R. Cristovao Colombo, 2265, S. Jose Rio Preto, SP, CEP 15054-000
dc.rights.accessRightsAcesso restrito
dc.identifier.scopus2-s2.0-8744276241
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt
dc.identifier.lattes0947193347312157
dc.identifier.lattes1445259468526188
dc.identifier.orcid0000-0002-0970-4288
unesp.author.lattes0947193347312157
unesp.author.lattes1445259468526188
unesp.author.orcid0000-0002-0970-4288[4]
unesp.author.orcid0000-0002-6682-2934[1]
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