Análise retrospectiva da toxicidade de gotas otológicas, medicamentos tópicos nasais e orofaríngeos registrada na Grande São Paulo.
Alternative titleRetrospective analysis of toxicity of eardrops, topical nasal and oropharyngeal medicines, documented in São Paulo, Brazil
MetadataShow full item record
BACKGROUND: Retrospective analysis of human toxicity files involving topical medicines for treatment of upper airways diseases (eardrops, topical nasal medicines, lozenges, drops and sprays for oropharyngeal affections). METHODS: Thirty-four brands of eardrops, 48 of topical nasal medicines and 22 of tablets, lozenges and sprays for oropharyngeal affections were selected, from a total of 104 products available in Brazil. We analyzed the registries in the electronic database from the Poison Control Centre of São Paulo (CCI-Jabaquara), Brazil, for the period from January 1996 through December 2000. The cases related to selected pharmaceuticals were collected. RESULTS: 10,823 cases of human toxicity caused by medicines were voluntarily reported to CCI-Jabaquara. Topical medicines for treatment of upper airways diseases accounted for 291 cases (2.68%), from which 240 (82.5%) represented poisoning; 12 (4.1%) involved ear drops, 268 (92%), topical nasal medicines and 11 (3.9%), topical medicines for oropharyngeal affections. Among topical nasal medicines, vasoconstrictors predominated (233 cases), and among medicines for oropharyngeal affections, it was tetracaine (four cases). Considering age distribution, toxicity predominated significantly in children aged from 1 to 4 years (p=0.0003). The main causes of toxicity were: accidental intake of medicines (43%) and error in drug administration (14.8%). Hypereflexia and vomiting were the most frequent symptoms related to toxicity. CONCLUSIONS: There was significant incidence of systemic toxicity due to eardrops, topical nasal and oropharyngeal medicines in children 1 to 4 years-old, whose main cause was accidental intake of these medicines.
How to cite this document
Showing items related by title, author, creator and subject.
Balbani, Aracy Pereira Silveira; Stelzer, Lucilena Bardella ; Montovani, Jair Cortez (Revista Brasileira de Otorrinolaringologia, 2006) [Artigo]Aim: To evaluate the presence of preservatives, dyes, sweeteners and flavouring substances in 73 pharmaceutical preparations of 35 medicines for oral administration, according to drug labeling information about the excipients. ...
Viegas-Junior, Cláudio ; Danuello, Amanda ; Bolzani, Vanderlan da Silva ; Barreiro, Eliezer J.; Fraga, Carlos Alberto M. (Current Medicinal Chemistry, 2007) [Resenha]Molecular hybridization is a new concept in drug design and development based on the combination of pharmacophoric moieties of different bioactive substances to produce a new hyrid compound with improved affinity and ...
Farmacología en la tercera edad: Medicamentos de uso continuo y peligros de la interacción medicamentosa Haddad, Marcela Filié ; Takamiya, Aline Satie ; da Silva, Eulália Maria Martins ; Barbosa, Débora de Barros (Gerokomos, 2009) [Artigo]Introduction: It was observed a considerable growth of elderly people. They are who use more medicines. The physiological changes associated with the age advancing can make pharmacokinetic and pharmacodynamic alterations. ...