New bioactive metabolites produced by Phomopsis cassiae, an endophytic fungus in Cassia spectabilis

Carregando...
Imagem de Miniatura

Data

2005-11-01

Autores

Silva, Geraldo H. [UNESP]
Araújo, Angela Regina [UNESP]
Telesa, Helder L. [UNESP]
Trevisana, Henrique C. [UNESP]
Bolzani, Vanderlan da Silva [UNESP]
Young, Maria C. M.
Pfenning, Ludwig H.
Eberlind, Marcos N.
Haddad, Renato
Costa-Netoe, Claudio M.

Título da Revista

ISSN da Revista

Título de Volume

Editor

Resumo

Two new metabolites, ethyl 2,4-dihydroxy-5,6-dimethylbenzoate (1) and phomopsilactone (2) were isolated from Phomopsis cassiae, an endophytic fungus in Cassia spectabilis. Their structures were elucidated by 1D and 2D NMR, MS and IR spectral data. Compounds 1 and 2 displayed strong antifungal activity against the phytopatogenic fungi Cladosporium cladosporioides and C. sphaerospermum, as well as cytotoxicity against human cervical tumor cell line (HeLa), in in vitro assays. ©2005 Sociedade Brasileira de Química.

Descrição

Palavras-chave

Antifungal activity, Cassia spectabilis, Cytotoxic metabolites, Endophytic fungi, Phomopsis cassiae

Como citar

Journal of the Brazilian Chemical Society, v. 16, n. 6 B, p. 1463-1466, 2005.