Synthesis of potentially bioactive PABA-related N-(aminoalkyl)lactamic amino acids and esters via selective SNAr reactions
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Data
2011-01-01
Autores
Goncalves, Renato S. [UNESP]
Abdelnur, Patricia V.
Santos, Vanessa G.
Simas, Rosineide C.
Eberlin, Marcos N.
Magalhaes, Alvicler
Perez Gonzalez, Eduardo R. [UNESP]
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Editor
Springer
Resumo
Potentially bioactive N-(aminoalkyl)lactamic amino acids and esters were synthesized in satisfactory to good yields by SNAr reactions of aromatic acids with N-(3-aminopropyl)lactams followed by esterification with tertiary amino alcohols. The addition-elimination SNAr mechanism was confirmed by NMR and MS measurements.
Descrição
Palavras-chave
PABA derivatives, Lactams, Potential bio-activity, SNAr reaction
Como citar
Amino Acids. New York: Springer, v. 40, n. 1, p. 197-204, 2011.