Uso da suplementação de LH recombinante na estimulação ovariana com protocolos de FSH recombinante e agonistas do GnRH: Uma revisão da literatura
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Data
2006-10-01
Autores
Oliveira, J. B A
Mauri, A. L. [UNESP]
Petersen, C. G. [UNESP]
Martins, A. M C [UNESP]
Cornicelli, J.
Cavagna, M.
Pontes, Anaglória [UNESP]
Baruffi, R. L R
Franco, J. G. [UNESP]
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Resumo
The purpose of this review was to assess the efficacy of recombinant LH (r-LH) supplementation for controlled ovarian stimulation in recombinant FSH (r-FSH) and GnRH-agonist (GnRH-a) protocol for IVF/ICSI cycles. Search strategies included on-line surveys of databases from 1990 to 2006. Four trials fulfilled the inclusion criteria (Lisi et al. 2002, Humaidan et al. 2004, Marrs et al. 2004, Tarlatzis et al. 2006). When the review was carried out advantages were observed for the r-LH supplementation protocol with respect to a fewer days of stimulation, a fewer total amount of r-FSH administered and a higher serum estradiol levels on the day of hCG administration. However, these differences were not observed in number of oocyte retrieved, number of mature oocytes, clinical pregnancy per oocyte retrieval, implantation and miscarriage rates. Nevertheless, more randomized controlled trials are necessary before evidence-based recommendations regarding exogenous r-LH supplementation in ovarian stimulation protocols with r-FSH and GnRH-a for assisted reproduction treatment can be provided.
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Palavras-chave
GnRH agonist, Ovarian stimulation, Recombinant FSH (r-FSH), Recombinant LH (r-LH), buserelin, chorionic gonadotropin, estradiol, leuprorelin, placebo, recombinant follitropin, recombinant luteinizing hormone, clinical trial, combination chemotherapy, controlled clinical trial, data base, dose response, drug efficacy, drug mechanism, estradiol blood level, female infertility, fertilization in vitro, hormone substitution, human, intracytoplasmic sperm injection, medical literature, monotherapy, nidation, oocyte maturation, ovary function, randomized controlled trial, review, spontaneous abortion
Como citar
Jornal Brasileiro de Reproducao Assistida, v. 10, n. 4, p. 40-46, 2006.