Effect of topical application of 5-FU on the corneoscleral limbus of rabbits
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Data
2007-04-01
Autores
Ferraz, Lucieni C.B. [UNESP]
Schellini, Silvana Artioli [UNESP]
Marques, Mariângela Esther Alencar [UNESP]
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Resumo
• Aim: To observe the effects of topical application of 5-fluorouracil (5-FU) on the rabbits corneal limbus. • Methods: 5-FU was applied topically to the corneoscleral region of rabbits eyes. The animals were sacrificed immediately or 7, 15, 30 and 60 days later, and tissues were submitted to histological examination. • Results: All animals presented corneoscleral deepithelization close to the site of application during the immediate post-operative period, whereas on the 4th postoperative day ulceration was no longer present. Histological examination showed absence of epithelium and slight edema. After one week (G2), 2 animals presented epithelial defects, thickened epithelium with larger basal cells and loose chromatin, and slight subepithelial edema. The remaining groups showed no alterations. • Conclusion: The 5-FU topically on the corneoscleral limbus postpone the epitelization.
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Palavras-chave
5-fluorouracil, Antimitotic agent, Histopathology, Rabbits, Topical application, fluorouracil, animal experiment, animal model, animal tissue, controlled study, cornea edema, cornea epithelium, cornea limbus, drug effect, histology, nonhuman, postoperative period, rabbit
Como citar
International Journal of Ophthalmology, v. 7, n. 2, p. 291-293, 2007.