Cytokine gene variants and venous thrombotic risk in the BRATROS (BRAZILIAN THROMBOSIS STUDY)
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Data
2007-05-21
Autores
Pieroni, Fabiano
Lourenço, Dayse M.
Morelli, Vânia M.
Maffei, Francisco Humberto de Abreu [UNESP]
Zago, Marco A.
Franco, Rendrik F.
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Introduction: Venous thrombosis (VT) and inflammation are two closely related entities. In the present investigation we assessed whether there is a relation between genetic modifiers of the inflammatory response and the risk of VT. Materials and methods: 420 consecutive and unrelated patients with an objective diagnosis of deep VT and 420 matched controls were investigated. The frequencies of the following gene polymorphisms were determined in all subjects: TNF-α- 308 G/A, LT-α+ 252 A/G, IL-6-174 G/C, IL1-ra 86 bp VNTR, IL-10-1082 A/G and CD-31 125 C/G. Results: Overall odds ratio (OR) for VT related to TNF-α- 308 G/A, LT-α+ 252 A/G, IL-6-174 G/C, A1 allele (4 bp repeat) of the IL1-ra 86 bp VNTR, IL-10-1082 A/G and CD-31 125 C/G were respectively: 1.0 (CI95: 0.8-1.5), 1.3 (CI95: 1.0-1.7), 1.1 (CI95: 0.9-1.5), 1.6 (CI95: 1-2.5), 1.2 (CI95: 0.8-1.7) and 0.8 (CI95: 0.6-1.1). A possible interaction between polymorphisms was observed only for the co-inheritance of the mutant alleles of the LT-α+ 252 A/G and IL-10-1082 G/A polymorphisms (OR = 2; CI95: 1.1-3.8). The risk of VT conferred by factor V Leiden and FII G20210A was not substantially altered by co-inheritance with any of the cytokine gene polymorphisms. Conclusions: Cytokine gene polymorphisms here investigated did not significantly influence venous thrombotic risk. © 2006 Elsevier Ltd. All rights reserved.
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Coagulation, Cytokines, Inflammation, Polymorphisms, Thrombosis, Venous thromboembolism, blood clotting factor 11, blood clotting factor 5 Leiden, CD31 antigen, cytokine, interleukin 1 receptor blocking agent, interleukin 10, interleukin 6, lymphotoxin, tumor necrosis factor alpha, cardiovascular risk, deep vein thrombosis, genetic polymorphism, inflammation, major clinical study, medical research, Base Sequence, Case-Control Studies, DNA Primers, Interleukin 1 Receptor Antagonist Protein, Interleukin-10, Interleukin-6, Lymphotoxin-alpha, Middle Aged, Odds Ratio, Polymorphism, Genetic, Tumor Necrosis Factor-alpha, Variation (Genetics), Venous Thrombosis
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Thrombosis Research, v. 120, n. 2, p. 221-229, 2007.