Bone healing in critical-size defects treated with bioactive glass/calcium sulfate: A histologic and histometric study in rat calvaria
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Data
2007-06-01
Autores
Furlaneto, Flávia A. C. [UNESP]
Nagata, Maria José Hitomi [UNESP]
Fucini, Stephen E.
Deliberador, Tatiana M. [UNESP]
Okamoto, Tetuo [UNESP]
Messora, Michel R. [UNESP]
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Objective: The purpose of this study was to analyze histologically the influence of bioactive glass (BG) with or without a calcium sulfate (CS) barrier on bone healing in surgically created critical-size defects (CSD) in rat calvaria. Material and methods: A CSD was made in each calvarium of 48 rats. They were divided into three groups: C (control): blood clot only; BG: defect filled with BG; and BG/CS: defect filled with BG covered by a CS barrier. Animals were euthanized at 4 or 12 weeks. Formation of new bone was evaluated histomorphometrically. Results: No defect completely regenerated with bone. BG particles were observed in Groups BG and BG/CS at both periods of analysis. The thickness throughout the healing area in Groups BG and BG/CS was similar to the original calvarium, while Group C presented a thin connective tissue in the center of the defect in both periods of analysis. At 4 weeks, Groups C and BG/CS presented significantly more bone formation than Group BG. No significant differences were found between Groups C and BG/CS. At 12 weeks, no significant differences in the amount of bone formation were observed among the three groups. When comparing 4 and 12 weeks, there was a significant increase in new bone formation within groups BG and BG/CS, but not C. Conclusion: BG particles, used with or without a CS barrier, maintained the volume and contour of the area grafted in CSD. However, they did not lead to a significant difference in bone formation when compared with control at 12 weeks post-operative. © 2007 Blackwell Munksgaard.
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Palavras-chave
Bioactive, Bone regeneration, Bone substitutes, Calcium sulfate, Glass, Biogran, biomaterial, calcium sulfate, glass, unclassified drug, animal, bone regeneration, cytology, drug effect, male, randomization, rat, skull, Wistar rat, Animals, Biocompatible Materials, Bone Regeneration, Calcium Sulfate, Male, Random Allocation, Rats, Rats, Wistar, Skull
Como citar
Clinical Oral Implants Research, v. 18, n. 3, p. 311-318, 2007.