Vernonia polyanthes as a new source of antiulcer drugs
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Methanolic (VPME) and chloroformic (VPCL) extracts, obtained from the aerial parts of Vernonia polyanthes, were investigated for its antiulcerogenic properties. Administration of VPME (250 mg/kg) and VPCL (50 mg/kg) significantly inhibited the gastric mucosa damage (64% and 90%, respectively) caused by absolute ethanol (p.o.). Otherwise, in NSAID-induced gastric damage, their gastroprotective effects have decreased. Since the VPCL extract resulted to be more effective than the VPME we focused our efforts over VPCL action mechanism of action. © 2007 Elsevier B.V. All rights reserved.
How to cite this document
Barbastefano, Victor et al. Vernonia polyanthes as a new source of antiulcer drugs. Fitoterapia, v. 78, n. 7-8, p. 545-551, 2007. Available at: <http://hdl.handle.net/11449/70008>.
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