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dc.contributor.authorLira, Walclecio de Moraes [UNESP]
dc.contributor.authorDos Santos, Fabio Vieira [UNESP]
dc.contributor.authorSannomiya, Miriam [UNESP]
dc.contributor.authorRodrigues, Clenilson Martins [UNESP]
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorVaranda, Eliana Aparecida [UNESP]
dc.date.accessioned2014-05-27T11:22:48Z
dc.date.available2014-05-27T11:22:48Z
dc.date.issued2008-03-01
dc.identifierhttp://dx.doi.org/10.1089/jmf.2007.553
dc.identifier.citationJournal of Medicinal Food, v. 11, n. 1, p. 111-119, 2008.
dc.identifier.issn1096-620X
dc.identifier.urihttp://hdl.handle.net/11449/70320
dc.description.abstractByrsonima basiloba A. Juss. species is a native arboreal type from the Brazilian cerrado (tropical American savanna), and the local population uses it to treat diseases, such as diarrhea and gastric ulcer. It belongs to the Malpighiaceae family, and it is commonly known as murici. Considering the popular use of B. basiloba derivatives and the lack of pharmacological potential studies regarding this vegetal species, the mutagenic and antimutagenic effect of methanol (MeOH) and chloroform extracts were evaluated by the Ames test, using strains TA97a, TA98, TA100, and TA102 of Salmonella typhimurium. No mutagenic activity was observed in any of the extracts. To evaluate the antimutagenic potential, direct and indirect mutagenic agents were used: 4 nitro-o-phenylenediamine, sodium azide, mitomycin C, aflatoxin B1, benzo[a]pyrene, and hydrogen peroxide. Both the extracts evaluated showed antimutagenic activity, but the highest value of inhibition level (89%) was obtained with the MeOH extract and strain TA100 in the presence of aflatoxin B1. Phytochemical analysis of the extracts revealed the presence of n-alkanes, lupeol, ursolic and oleanolic acid, (+)-catechin, quercetin-3-O-α-L-arabinopyranoside, gallic acid, methyl gallate, amentoflavone, quercetin, quercetin-3-O-(2″-O-galloyl)-β-D- galactopyranoside, and quercetin-3-O-(2″-O-galloyl)-α-L- arabinopyranoside. © 2008 Mary Ann Liebert, Inc.en
dc.format.extent111-119
dc.language.isoeng
dc.relation.ispartofJournal of Medicinal Food
dc.sourceScopus
dc.subjectAmes test
dc.subjectAntimutagenic
dc.subjectByrsonima
dc.subjectMutagenic
dc.subject4 nitro o phenylenediamine
dc.subjectaflatoxin B1
dc.subjectalkane
dc.subjectamentoflavone
dc.subjectbenzo[a]pyrene
dc.subjectByrsonima basiloba extract
dc.subjectcatechin
dc.subjectchloroform
dc.subjectgallic acid
dc.subjectgallic acid methyl ester
dc.subjecthydrogen peroxide
dc.subjectlupeol
dc.subjectmethanol
dc.subjectmitomycin C
dc.subjectmutagenic agent
dc.subjectoleanolic acid
dc.subjectplant extract
dc.subjectquercetin
dc.subjectquercetin 3 o (2'' o galloyl) alpha dextro galactopyranoside
dc.subjectquercetin 3 o (2'' o galloyl) beta dextro galactopyranoside
dc.subjectquercetin 3 o alpha levo arabinopyranoside
dc.subjectquercetin 3 o beta galactopyranoside
dc.subjectquercetin derivative
dc.subjectsodium azide
dc.subjectunclassified drug
dc.subjectursolic acid
dc.subjectarboreal species
dc.subjectbacterial strain
dc.subjectByrsonima basiloba
dc.subjectcontrolled study
dc.subjectdrug effect
dc.subjectdrug inhibition
dc.subjectmutagen testing
dc.subjectmutagenicity
dc.subjectnonhuman
dc.subjectphytochemistry
dc.subjectpriority journal
dc.subjectSalmonella typhimurium
dc.subjectAntimutagenic Agents
dc.subjectChloroform
dc.subjectFlavonoids
dc.subjectMalpighiaceae
dc.subjectMethanol
dc.subjectMutagenicity Tests
dc.subjectMutagens
dc.subjectPlant Extracts
dc.subjectPlant Leaves
dc.titleModulatory effect of Byrsonima basiloba extracts on the mutagenicity of certain direct and indirect-acting mutagens in Salmonella typhimurium assaysen
dc.typeArtigo
dcterms.licensehttp://www.liebertpub.com/nv/resources-tools/self-archiving-policy/51/
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUNIVAP
dc.description.affiliationDepartment of Biological Sciences Faculty of Pharmaceutical Sciences of Araraquara São Paulo State University, Rodovia Araraquara-Jaú, Araraquara, São Paulo
dc.description.affiliationChemical Institute of Araraquara São Paulo State University, Araraquara, São Paulo
dc.description.affiliationDepartment of Biological Sciences Faculty of Pharmaceutical Sciences of Araraquara São Paulo State University, Rodovia Araraquara-Jaú, Km 1, 14801-902, SP
dc.description.affiliationResearch and Development Institute Vale Do Paraíba University UNIVAP, São José dos Campos, SP
dc.description.affiliationUnespDepartment of Biological Sciences Faculty of Pharmaceutical Sciences of Araraquara São Paulo State University, Rodovia Araraquara-Jaú, Araraquara, São Paulo
dc.description.affiliationUnespChemical Institute of Araraquara São Paulo State University, Araraquara, São Paulo
dc.description.affiliationUnespDepartment of Biological Sciences Faculty of Pharmaceutical Sciences of Araraquara São Paulo State University, Rodovia Araraquara-Jaú, Km 1, 14801-902, SP
dc.identifier.doi10.1089/jmf.2007.553
dc.rights.accessRightsAcesso restrito
dc.identifier.scopus2-s2.0-41349113443
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
dc.identifier.file2-s2.0-41349113443.pdf
dc.identifier.lattes7501930236496670
dc.identifier.orcid0000-0003-3032-2556
unesp.author.lattes7501930236496670
unesp.author.orcid0000-0003-3032-2556[5]
dc.relation.ispartofjcr1.954
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