Polyethylene gel in the subcutaneous tissue of rats: Histopathologic and systemic evaluation
MetadataShow full item record
Purpose: To evaluate the histological and systemic response to subcutaneous injection of polyethylene gel in rats. Methods: Twenty-one white male rats were divided into 3 groups (G): G1 and G2 received subcutaneous polyethylene gel injection in the dorsal midline and were sacrificed at 30 and 60 postoperative days, respectively. G3 was not exposed to the polyethylene gel and was sacrificed after 60 days. Blood levels of lactate dehydrogenase (LDH), creatine kinase (CK), and alkaline phosphatase (ALP) were evaluated. The heart, kidney, liver, adrenal gland, injection site, and adjacent tissues were histologically examined. The results were submitted to statistical analysis. Results: There was no clinical evidence of extrusion, reduction of the injected volume, or abnormalities in the adjacent tissues. Blood levels of CK and LDH were normal and similar in all groups. ALP levels were significantly lower in G2 than in G1 and G3. The systemic organs were normal on histological examination in the 3 groups evaluated. Microscopically, the polyethylene gel was surrounded by a thin pseudocapsule formation and minimal inflammatory cell response, which decreased from G1 to G2. Conclusion: The subcutaneous injection of polyethylene gel in rats elicited minimal local inflammatory response and no systemic side effects. Copyright © 2008 Informa Healthcare USA, Inc.
How to cite this document
Showing items related by title, author, creator and subject.
Kaminagakura, Kryscia Natsuaki ; Sato, Silvana Sue ; Sugino, Patricia ; Santos, Daniela Carvalho ; Kataki, Laryssa ; Padovani, Carlos Roberto ; Basmaji, Pierre ; Schellini, Silvana A. (Ophthalmic Plastic And Reconstructive Surgery, 2018) [Artigo]Purpose: To evaluate the suitability of Nanoskin((R)), a biomaterial derived from bacterial cellulose, as an alternate material for repairing the posterior lamellae of the eyelids. Methods: Forty guinea pigs received a ...
Peritoneal reactivity evaluation in horses subjected to experimental small colon enterotomy and treated with subcutaneous heparin Alonso, Juliana de Moura ; Rodrigues, Karoline Alves ; Yamada, Ana Lúcia Miluzzi ; Watanabe, Marcos Jun ; Alves, Ana Liz Garcia ; Rodrigues, Celso Antonio ; Hussni, Carlos Alberto (Veterinary Medicine International, 2014) [Artigo]Heparin is routinely administered in postoperative abdominal surgery aiming to prevent adhesions formation; however, there is no consensus indicating its effectiveness. This study evaluated the effect of heparin on peritoneal ...
Postoperative analgesic effects of intravenous, intramuscular, subcutaneous or oral transmucosal buprenorphine administered to cats undergoing ovariohysterectomy Giordano, Tatiana ; Steagall, Paulo V. M. ; Ferreira, Tatiana H. ; Minto, Bruno W. ; Rodolfo de Sa Lorena, Silvia Elaine ; Brondani, Juliana ; Luna, Stélio Pacca Loureiro (Veterinary Anaesthesia and Analgesia, 2010) [Artigo]ObjectiveTo compare the postoperative analgesic effects of intravenous (IV), intramuscular (IM), subcutaneous (SC) or oral transmucosal (OTM) buprenorphine administered to cats undergoing ovariohysterectomy.Study ...