Intestinal anti-inflammatory activity of coumarin and 4-hydroxycoumarin in the trinitrobenzenesulphonic acid model of rat colitis
MetadataShow full item record
Coumarins represent an important class of phenolic compounds with multiple biological activities, including inhibition of lipidic peroxidation and neutrophil-dependent anion superoxide generation, anti-inflammatory and immunosuppressor actions. All of these proprieties are essential for that a drug may be used in the treatment of inflammatory bowel disease. The present study examined intestinal anti-inflammatory activity of coumarin and its derivative, the 4-hydroxycoumarin on experimental ulcerative colitis in rats. This was performed in two different experimental settings, i.e. when the colonic mucosa is intact or when the mucosa is in process of recovery after an initial insult. The results obtained revealed that the coumarin and 4-hydroxycoumarin, at doses of 5 and 25 mg/kg, significantly attenuated the colonic damage induced by trinitrobenzenesulphonic acid (TNBS) in both situations, as evidenced macroscopically, microscopically and biochemically. This effect was related to an improvement in the colonic oxidative status, since coumarin and 4-hydroxycoumarin prevented the glutathione depletion that occurred as a consequence of the colonic inflammation. © 2008 Pharmaceutical Society of Japan.
How to cite this document
Showing items related by title, author, creator and subject.
Utilização do metabolismo protéico ( 15N-glicina) na detecção precoce de agravamento da atividade da doença em pacientes portadores de retocolite ulcerativa inespecífica Dichi, Isaias; Dichi, Jane B.; Frenhane, Patrícia ; Corrêa, Camila Renata ; Angeleli, Aparecida Y.O. ; Bicudo, Mitsue H. ; Rodrigues, Maria A.M. ; Victória, Carlos R. ; Burini, Roberto Carlos (Arquivos de Gastroenterologia, 1998) [Artigo]Disease activity was assessed in 10 (five males and five females) ulcerative colitis patients through the following parameters: clinical, laboratory, sigmoidoscopic and histological. Protein metabolism was also assessed ...
Reativação da retocolite ulcerativa com o uso de droga anti-inflamatória não esteróide: relato de caso e revisão da literatura Dichi, I. ; Dichi, J. B. ; Frenhane, P. ; Rodrigues, M. A. ; Burini, Roberto Carlos ; Victória, C. R. (Arquivos de Gastroenterologia, 1995) [Resenha]The case of a patient with ulcerative colitis and isolated sacro-ileitis is presented. She suffered reactivation of the intestinal disease with diclofenac. The patient was allergic to sulfasalazine and was using fish oil ...
De Almeida, Ana Beatriz Albino; Sánchez-Hidalgo, Marina; Martín, Antonio Ramón; Luiz-Ferreira, Anderson; Trigo, José Roberto; Vilegas, Wagner ; Santos, Lourdes Campaner dos ; Souza-Brito, Alba Regina Monteiro; De La Lastra, Catalina Alarcón (Journal of Ethnopharmacology, 2013) [Artigo]Ethnopharmacological relevance: In Brazilian traditional medicine, Arctium lappa (Asteraceae), has been reported to relieve gastrointestinal symptoms. Aim of the study: In the present study, we investigated the effects of ...