MetadataShow full item record
The anthracyclines constitute a group of drugs widely used for the treatment of a variety of human tumors. However, the development of irreversible cardiotoxicity has limited their use. Anthracycline-induced cardiotoxicity can persist for years with no clinical symptoms. However, its prognosis becomes poor after the development of overt heart failure, possibly even worse than ischemic or idiopathic dilated cardiomyopathies. Due to the successful action of anthracyclines as chemotherapic agents, several strategies have been tried to prevent/ attenuate their side effects. Although anthracycline-induced injury appears to be multifactorial, a common denominator among most of the proposed mechanisms is cellular damage mediated by reactive oxygen species. However, it remains controversial as to whether antioxidants can prevent such side effects given that different mechanisms may be involved in acute versus chronic toxicity. The present review applies a multisided approach to the critical evaluation of various hypotheses proposed over the last decade on the role of oxidative stress in cardiotoxicity induced by doxorubicin, the most used anthracycline agent. The clinical diagnosis and treatment is also discussed. © 2008 Bentham Science Publishers Ltd.
How to cite this document
Showing items related by title, author, creator and subject.
Soriano, Eline A. ; Gaiolla, Paula Schmidt Azevedo ; Miot, Hélio Amante ; Minicucci, Marcos Ferreira ; Pansani, Mariele C. ; Matsubara, Luiz Shiguero ; Okoshi, Katashi ; Zornoff, Leonardo Antonio Mamede ; Matsubara, Beatriz Bojikian ; Paiva, Sergio A.R. (International Journal of Cardiology, 2013) [Artigo]Background: Currently, 13-cis-retinoic acid (13-cis-RA) is the most effective therapy for acne. Isotretinoin, a first-generation synthetic 13-cis-RA compound, is associated with numerous adverse effects. To investigate the ...
Damatto, R. L. ; Martinez, P. F. ; Lima, A. R R ; Cezar, M. D M ; Campos, D. H S ; Oliveira Junior, S. A. ; Guizoni, D. M. ; Bonomo, C. ; Nakatani, B. T. ; Dal Pai Silva, M. et al. (International Journal of Cardiology, 2013) [Artigo]Background: Although skeletal muscle atrophy and changes in myosin heavy chain (MyHC) isoforms have often been observed during heart failure, their pathophysiological mechanisms are not completely defined. In this study ...
Waist circumference, but not body mass index, is a predictor of ventricular remodeling after anterior myocardial infarction Cogni, Ana Lucia ; Farah, Elaine ; Minicucci, Marcos Ferreira ; Gaiolla, Paula Schmidt Azevedo ; Okoshi, Katashi ; Matsubara, Beatriz Bojikian ; Zanati, Silméia G. ; Paiva, Sergio A.R. ; Zornoff, Leonardo Antonio Mamede (Nutrition, 2013) [Artigo]Objective: The impact of obesity on ventricular remodeling after myocardial infarction (MI) is still poorly understood. Therefore, the aim of this study was to evaluate the role of waist circumference (WC) and body mass ...