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dc.contributor.authorBelo, M. A A [UNESP]
dc.contributor.authorSouza, L. M. [UNESP]
dc.contributor.authorSoares, V. E. [UNESP]
dc.contributor.authorSobreira, M. F R
dc.contributor.authorCasol, D. M S
dc.contributor.authorToma, S. B.
dc.date.accessioned2014-05-27T11:24:32Z
dc.date.available2014-05-27T11:24:32Z
dc.date.issued2009-12-01
dc.identifierhttp://ojs.c3sl.ufpr.br/ojs2/index.php/veterinary/article/view/12633
dc.identifier.citationArchives of Veterinary Science, v. 14, n. 2, p. 74-82, 2009.
dc.identifier.issn1517-784X
dc.identifier.urihttp://hdl.handle.net/11449/71401
dc.description.abstractThe aims of this investigation was to evaluate the effect of hepatoprotective treatments with a compound prepared by the association of N-Acetyl DL-Methionine (5%) + Choline chloride (2%) + Caffeine (1%) + Thiamine hydrochloride (1%) + Nicotinamida (0,5%)+ Pyridoxine hydrochloride (0.04%), administered through intramuscular (IM) route, at doses of 0.2, 0.6 and 1.0 mL/kg of BW, through the study of leukocytes responses in rats submitted to acute intoxication with CCl4. 147 females were randomized into 21 groups, performing five different treatments, which were evaluated seven animals in four periods: two, four, six and eight days after CCl4-induced intoxication. In this study, it was observed absolute eosinophilia and monocytosis in animals untreated and treated with the lowest dose of 0.2 mL. These responses were significantly better in animals treated with 0.6 and 1.0 mL/ kg BW. The untreated animals showed thrombocytopenia, when compared to treated animals. Absolute neutropenia and lymphocytosis was observed in all rats intoxicated with CCl4, there is no difference among treatments. The analysis of white blood cells demonstrated that the hepatoprotective treatments favored the leukocyte response, by act beneficially on the population of these cells, supporting the hypothesis that these events may reduce the deleterious effects in liver tissue after intoxication by CCl4.en
dc.format.extent74-82
dc.language.isopor
dc.relation.ispartofArchives of Veterinary Science
dc.sourceScopus
dc.subjectCarbon tetrachlorideen
dc.subjectHepatoprotectiveen
dc.subjectLeukocytesen
dc.subjectRatsen
dc.subjectAnimaliaen
dc.subjectRattusen
dc.subjectRattus norvegicusen
dc.titleTratamento hepatoprotetor favorece a resposta leucocitária de ratos wistar intoxicados por CCL4pt
dc.title.alternativeHepatoprotective treatment improves leukocyte responses of Wistar rats intoxicated by CCl4en
dc.typeArtigo
dcterms.licensehttp://ojs.c3sl.ufpr.br/ojs2/index.php/veterinary/about/editorialPolicies#openAccessPolicy
dc.contributor.institutionUnicastelo
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionEmpresa Ouro Fino Saúde Animal Ltda
dc.description.affiliationUnicastelo, Descalvado/SP
dc.description.affiliationCPPAR- Depto. Patologia Veterinária FCAV/Unesp Campus de Jaboticabal
dc.description.affiliationDepto. de Pesquisas Veterinárias Empresa Ouro Fino Saúde Animal Ltda
dc.description.affiliationUnespCPPAR- Depto. Patologia Veterinária FCAV/Unesp Campus de Jaboticabal
dc.rights.accessRightsAcesso aberto
dc.identifier.scopus2-s2.0-77955165702
dc.identifier.file2-s2.0-77955165702.pdf
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