• Obtenção e caracterização de filamentos compostos por fosfatos de cálcio e polímeros para impressão 3d de scaffolds 

  Queiroz, Lúcio Pedro Alcântara (Universidade Estadual Paulista (Unesp), 2020) [Dissertação de mestrado]

  A perda de um órgão ou de parte do corpo implica perda da função. Isso, pode provocar transtornos sociais e psicológicos. Esse cenário vem se tornando cada vez mais comum com aumento da expectativa de vida da população. ...

• New Insights into the Mechanism of Action of the Cyclopalladated Complex (CP2) in Leishmania: Calcium Dysregulation, Mitochondrial Dysfunction, and Cell Death 

  Velásquez, Angela Maria Arenas; Bartlett, Paula; Linares, Irwin Alexander Patino; Passalacqua, Thais G.; Teodoro, Daphne D. L.; Imamura, Kely B.; Virgilio, Stela; Tosi, Luiz R. O.; Leite, Aline de Lima; Buzalaf, Marilia A. R. et al. (Antimicrobial Agents and Chemotherapy, 2022) [Artigo]

  The current treatment of leishmaniasis is based on a few drugs that present several drawbacks, such as high toxicity, difficult administration route, and low efficacy. These disadvantages raise the necessity to develop ...

• Identificação, caracterização e síntese peptídica associada à enolase de Sporothrix schenckii: aplicação em plataforma imunossensora eletroquímica portátil para o diagnóstico da Esporotricose Felina. 

  Castilho, Bruna Mateus de (Universidade Estadual Paulista (Unesp), 2022) [Tese de doutorado]

  A esporotricose é uma infecção causada por fungos de espécies pertencentes ao gênero Sporothrix, afetando humanos e animais. Esta infecção apresenta ampla distribuição mundial, mas no Brasil é considerada emergente e ...

• Avaliação biológica de extratos obtidos das partes aéreas e plântulas de Physalis angulata L. (solanaceae) 

  Donadon, Maria Leonor Beneli (Universidade Estadual Paulista (Unesp), 2021) [Tese de doutorado]

  RESUMO As plantas tornaram-se material constante em pesquisas que possam encontrar novas moléculas com atividade antimicrobiana, a fim de possibilitar inovações e trazer benefícios à população. Além do potencial natural ...

• O papel da sinalização química via sensor histidina quinase QseC na virulência de Escherichia coli enteroagregativa Stx+ 

  Machado Ribeiro, Tamara Renata (Universidade Estadual Paulista (Unesp), 2021) [Tese de doutorado]

  Escherichia coli enteroagregativa (EAEC) está envolvida em casos de diarreia aguda e persistente (≥14 dias) em crianças e adultos de países desenvolvidos e em desenvolvimento. Possui um padrão de adesão exclusivo em cultivo ...

• Desenvolvimento, síntese e caracterização de lipossomas conjugados com análogos de sideróforos e estudo in vitro como estratégia terapêutica para tuberculose 

  Ribeiro, Camila Maringolo (Universidade Estadual Paulista (Unesp), 2022) [Tese de doutorado]

  A tuberculose (TB) é uma doença infecciosa que afeta milhões de pessoas anualmente, é necessário um longo tratamento para a cura, especialmente para os casos de resistência a antibióticos. Outra particularidade de Mycobacterium ...

• Rethinking Breast Cancer Chemoprevention: Technological Advantages and Enhanced Performance of a Nanoethosomal-Based Hydrogel for Topical Administration of Fenretinide 

  Apolinário, Alexsandra Conceição; Salata, Giovanna Cassone; de Souza, Marcelo Medina; Chorilli, Marlus ; Lopes, Luciana Biagini (AAPS PharmSciTech, 2022) [Artigo]

  Herein, we developed an ethosomal hydrogel based on three types of ethosomes: simple, mixed (surfactant-based micelles and lipid vesicles) or binary (comprising two type of alcohols). Ethanol injection was employed for ...

• Folic acid-modified curcumin-loaded liposomes for breast cancer therapy 

  Luiz, Marcela Tavares; Dutra, Jessyca Aparecida Paes ; Ribeiro, Taís de Cássia ; Carvalho, Gabriela Corrêa ; Sábio, Rafael Miguel ; Marchetti, Juliana Maldonado; Chorilli, Marlus (Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2022) [Artigo]

  Breast cancer is the commonest cancer among women, with more than 2 million cases per year and a lethality rate of 17.7%. The treatment of breast cancer still being a challenge due to the high heterogeneity of tumor cells. ...

• Antimicrobial Peptides as an Alternative for the Eradication of Bacterial Biofilms of Multi-Drug Resistant Bacteria 

  de Pontes, Janaína Teixeira Costa ; Borges, Anna Beatriz Toledo ; Roque-Borda, Cesar Augusto ; Pavan, Fernando Rogério (Pharmaceutics, 2022) [Resenha]

  Bacterial resistance is an emergency public health problem worldwide, compounded by the ability of bacteria to form biofilms, mainly in seriously ill hospitalized patients. The World Health Organization has published a ...

• Immature instars of three species of Rhodnius Stål, 1859 (Hemiptera, Reduviidae, Triatominae): morphology, morphometry, and taxonomic implications 

  Lázari Cacini, Gustavo ; de Oliveira, Jader; Belintani, Tiago; dos Santos Souza, Éder; Olaia, Nicoly ; Pinto, Mara Cristina ; da Rosa, João Aristeu (Parasites and Vectors, 2022) [Artigo]

  Background: Among the 18 genera of the Triatominae subfamily, three stand out for their diversity and epidemiological importance: Triatoma, Panstrongylus, and Rhodnius. Rhodnius includes 21 species that can transmit ...

• Glioblastoma multiforme targeted delivery of docetaxel using bevacizumab-modified nanostructured lipid carriers impair in vitro cell growth and in vivo tumor progression 

  Di Filippo, Leonardo Delello ; Lobato Duarte, Jonatas ; Hofstätter Azambuja, Juliana; Isler Mancuso, Rubia; Tavares Luiz, Marcela; Hugo Sousa Araújo, Victor ; Delbone Figueiredo, Ingrid ; Barretto-de-Souza, Lucas ; Miguel Sábio, Rafael ; Sasso-Cerri, Estela et al. (International Journal of Pharmaceutics, 2022) [Artigo]

  Glioblastoma multiforme (GBM) is the most common malignant brain cancer, characterized by high invasiveness and poor prognosis. Docetaxel (DTX) is a chemotherapeutic drug with promising anti-tumor properties. However, ...

• PIMREG expression level predicts glioblastoma patient survival and affects temozolomide resistance and DNA damage response 

  Serafim, Rodolfo Bortolozo; Cardoso, Cibele; Arfelli, Vanessa Cristina; Valente, Valeria ; Archangelo, Leticia Fröhlich (Biochimica et Biophysica Acta - Molecular Basis of Disease, 2022) [Artigo]

  PIMREG expression strongly correlates with cellular proliferation in both malignant and normal cells. Throughout embryo development, PIMREG expression is prominent in the central nervous system. Recent studies have described ...

• Synthesis and Evaluation of the Antifungal and Toxicological Activity of Nitrofuran Derivatives 

  Vaso, Carolina Orlando ; Pandolfi, Fabiana; Bila, Níura Madalena ; De Vita, Daniela; Bortolami, Martina; Mendes-Giannini, Maria José Soares ; Tudino, Valeria; Costi, Roberta; Costa-Orlandi, Caroline Barcelos ; Fusco-Almeida, Ana Marisa et al. (Pharmaceutics, 2022) [Artigo]

  Fungal diseases affect more than 1 billion people worldwide. The constant global changes, the advent of new pandemics, and chronic diseases favor the diffusion of fungal pathogens such as Candida, Cryptococcus, Aspergillus, ...

• Cyrhetrenyl and cymantrenyl N-acylhydrazone complexes based on isoniazid: Synthesis, characterization, X-ray crystal structures and antitubercular activity evaluation 

  Mallea, Mario; Acuña, Alejandra; Klahn, A. Hugo; Artigas, Vania; Pavan, Fernando Rogério ; Demarqui, Fernanda Manaia ; Lemus, Luis; Jara, Danilo H.; Toro, Patricia M. (Journal of Organometallic Chemistry, 2022) [Artigo]

  Four organometallic N-acylhydrazones of the general formulae [M{(η5-C5H4)-CH[dbnd]N[sbnd]NH[sbnd]C(O)-(C5H4[sbnd]N)}(CO)3] [(with M = Re (5a) or Mn (6a)] and [M{(η5-C5H4)-C(Me)=N[sbnd]NH[sbnd]C(O)-(C5H4[sbnd]N)}(CO)3] ...

• HPMCAS-Coated Alginate Microparticles Loaded with Ctx(Ile21)-Ha as a Promising Antimicrobial Agent against Salmonella Enteritidis in a Chicken Infection Model 

  Roque-Borda, Cesar Augusto ; Souza Saraiva, Mauro de Mesquita ; Monte, Daniel F. M. ; Rodrigues Alves, Lucas Bocchini ; de Almeida, Adriana Maria ; Ferreira, Taísa Santiago ; de Lima, Túlio Spina ; Benevides, Valdinete Pereira ; Cabrera, Julia Memrava ; Claire, Sunil et al. (ACS Infectious Diseases, 2022) [Artigo]

  Salmonella enterica subsp. enterica serovar Enteritidis (S. Enteritidis) in poultry is most often transmitted by the fecal-oral route, which can be attributed to high population density. Upon encountering the innate immune ...

• Antifungal activity and toxicity of an octyl gallate-loaded nanostructured lipid system on cells and nonmammalian animals 

  Singulani, Junya L ; Scorzoni, Liliana ; Da Silva, Patricia B ; Nazaré, Ana C ; Polaquini, Carlos R ; Baveloni, Franciele G ; Chorilli, Marlus ; Regasini, Luis O ; Fusco-Almeida, Ana M ; Mendes-Giannini, Maria J.S. (Future Microbiology, 2022) [Artigo]

  Aim: Octyl gallate (OG) loaded into a nanostructured lipid system (NLS) was tested for antifungal activity and in vitro and in vivo toxicity. Methods & Results: The features of NLS-OG were analyzed by dynamic light scattering ...

• Antibacterial action and target mechanisms of zinc oxide nanoparticles against bacterial pathogens 

  Mendes, Carolina Rosai ; Dilarri, Guilherme ; Forsan, Carolina Froes ; Sapata, Vinícius de Moraes Ruy ; Lopes, Paulo Renato Matos ; de Moraes, Peterson Bueno; Montagnolli, Renato Nallin ; Ferreira, Henrique ; Bidoia, Ederio Dino (Scientific Reports, 2022) [Artigo]

  Zinc oxide nanoparticles (ZnO NPs) are one of the most widely used nanoparticulate materials due to their antimicrobial properties, but their main mechanism of action (MOA) has not been fully elucidated. This study ...

• Solid lipid nanoparticles loaded with curcumin: Development and in vitro toxicity against CT26 cells 

  Ganassin, Rayane; Da Silva, Victor Carlos Mello; Araujo, Victor Hugo Sousa; Tavares, Giulia Rosa; Da Silva, Patrícia Bento; Cáceres-Vélez, Paolin Rocio; Porcel, Joaquin E Martínez; Rodrigues, Mosar Corrêa; Andreozzi, Patrizia; Fernandes, Richard Perosa et al. (Nanomedicine, 2022) [Artigo]

  Aim: To develop a new curcumin carrier consisting of murumuru butter nanoparticles (SLN-Cs). Methods: A phase-inversion temperature method was used to produce SLN-Cs. The interaction of SLN-Cs with murine colon adenocarcinoma ...

• Recent advancement in drug development of nitro(NO2)-heterocyclic compounds as lead scaffolds for the treatment of Mycobacterium tuberculosis 

  Scarim, Cauê Benito; Pavan, Fernando Rogério (Drug Development Research, 2022) [Resenha]

  Tuberculosis (TB) is an infectious disease caused predominantly by Mycobacterium tuberculosis (Mtb). It was responsible for approximately 1.4 million deaths worldwide in 2019. The lack of new drugs to treat drug-resistant ...

• Understanding the role of electrostatic interactions on the association of 5-fluorouracil to chitosan-TPP nanoparticles 

  dos Santos, Aline Martins ; Carvalho, Suzana Gonçalves ; Ferreira, Leonardo Miziara Barboza ; Chorilli, Marlus ; Gremião, Maria Palmira Daflon (Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2022) [Artigo]

  Judicious design strategies should be considered powerful tools to better control the properties of chitosan (CS) and tripolyphosphate (TPP) particles. This study focused on understanding the role of the charge properties ...

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