Dornase alfa improves the health-related quality of life among Brazilian patients with cystic fibrosis - A one-year prospective study
MetadataShow full item record
Background: Health-related quality of life (HRQOL) measurements provide valuable information about the psychological and social impact of treatment on patients with cystic fibrosis (CF). This study evaluated the HRQOL of Brazilian patients with CF and assessed the changes in HRQOL domains over 1 year after dornase alfa (Pulmozyme) introduction. Patients and Methods: One hundred fifty-six stable patients with CF and 89 caregivers answered the Portuguese-validated version of the Cystic Fibrosis Questionnaire-Revised (CFQ-R) at baseline (T 0), and at 3 (T 1), 6 (T 2), 9 (T 3), and 12 (T 4) months of follow-up. Eighteen patientswere excluded because they did not fulfill the inclusion criteria. The patients were analyzed in two groups: those aged 6-11 years and those aged 14 years and older. ANOVA for observed repeated results and the last observation carried forward (LOCF) method for missing data were used for the statistical analysis. Results: After 1 year of follow-up, there was significant improvement in respiratory symptoms (T 4-T 0=8.1; 95% confidence interval (95% CI)=[2.1;14.0]; effect size (ES)=0.35; P<0.001), Emotional Functioning (T 4-T 0=5.6; 95% CI=[1.1;10.1]; ES=0.31; P<0.05), Social Functioning (T 4-T 0=6.0; 95% CI=[1.3;11.7]; ES=0.31; P<0.05), Body Image (T 4-T 0=11.9; 95% CI=[4.1;19.7]; ES=0.42; P<0.05), and Treatment Burden (T 4-T 0=5.3; 95% CI=[0.3;10.3]; ES=0.24; P<0.05) domains in the younger group. A significant improvement in Role Functioning (T 4-T 0=6.1; 95% CI=[1.1;11.1]; ES=0.40; P<0.05), Body Image (T 4-T 0=12.6; 95% CI=[3.5;21.7]; ES=0.46; P<0.05), and Weight (T 4-T 0=11.7; 95% CI=[1.8;21.6]; ES=0.40; P<0.05) was obtained in the older group. The caregivers' CFQ-R showed improvements in the Digestive Symptoms (T 4-T 0=5.5; 95% CI=[1.5;9.4]; ES=0.30; P<0.05), Respiratory Symptoms (T 4-T 0=7.6; 95% CI=[3.9;11.4]; ES=0.48; P<0.05), and Weight (T 4-T 0=10.1; 95% CI=[1.6;18.6]; ES=0.26; P<0.05) domains. Conclusion: The introduction of dornase alfa improved the HRQL of the patients with CF during the first year of treatment. © 2010 Wiley-Liss, Inc.
How to cite this document
Showing items related by title, author, creator and subject.
Genome-wide association study: Understanding the genetic basis of the gait type in Brazilian Mangalarga Marchador horses, a preliminary study Bussiman, Fernando de Oliveira; Aparecida dos Santos, Bruna ; Abreu Silva, Bárbara da Conceição; Mamani, Gerardo Cornelio Mamani; Grigoletto, Laís; Pereira, Guilherme Luis ; Ferraz, Guilherme de Camargo ; Ferraz, José Bento Sterman; Mattos, Elisângela Chicaroni; Eler, Joanir Pereira et al. (Livestock Science, 2020) [Artigo]The ECA23:22999655C>A DMRT3 variant has been described as a causative region for the four-beat gait in horses, however it remains uncertain for the two distinct gait types observed in the Brazilian Mangalarga Marchador ...
Gomes, M. C. ; Leite, D. M. G. ; Sambrano, J. R. ; Dias da Silva, J. H. ; de Souza, A. R. ; Beltran, A. (Surface Science, 2011) [Artigo]Periodic slab calculations based on density functional theory were performed at the B3LYP level to gain insight into the surfaces of wurtzite GaN nanostructures. The (10 (1) over bar0) and (11 (2) over bar0) GaN surfaces ...
Methodological contributions towards the study of health care production: lessons from a research study on barriers and access in mental health Merhy, Emerson Elias; Feuerwerker, Laura Camargo Macruz; Silva, Erminia (Salud Colectiva, 2012) [Artigo]This article presents methodological contributions and a conceptual innovation for thinking about the production of health care, stemming from a study on access and barriers in mental health carried out in the municipality ...