Search
Now showing items 1-10 of 30
Transcriptomic crosstalk between fungal invasive pathogens and their host cells: Opportunities and challenges for next-generation sequencing methods
(Journal of Fungi, 2016-03-01) [Resenha]
Fungal invasive infections are an increasing health problem. The intrinsic complexity of pathogenic fungi and the unmet clinical need for new and more effective treatments requires a detailed knowledge of the infection ...
SISTEMAS QUIMILUMINESCENTES COM PEROXIDASE (EC:1.11.1.7) E SUAS APLICACOES EM ANALISES CLINICAS
(Revista de Ciencias Farmaceuticas, 1995-01-01) [Resenha]
The enzyme horseradish peroxidase HRP (EC:1.11.1.7), has both acid and basic isoenzymes, catalyses a wide range of reactions (acting as an oxiredutase or an oxidase) and is thought capable of one- or two-electrons oxidations ...
A complexa fisiopatologia dos episódios vasooclusivos na anemia falciforme
(Revista de Ciencias Farmaceuticas, 2002-12-01) [Resenha]
Hemolytic anemia and vasoocclusion are the cardinal clinical features of sickle cell anemia. Vasoocclusion is a complex process involving not only the polymerization of deoxygenated sickle hemoglobin tetramers, but also ...
Molecular adjuvants that modulate regulatory T cell function in vaccination: A critical appraisal
(Pharmacological Research, 2018-03-01) [Resenha]
Adjuvants are substances used to enhance the efficacy of vaccines. They influence the magnitude and alter the quality of the adaptive immune response to vaccine antigens by amplifying or modulating different signals involved ...
Fungal diseases: could nanostructured drug delivery systems be a novel paradigm for therapy?
(International Journal Of Nanomedicine, 2016-01-01) [Resenha]
Invasive mycoses are a major problem for immunocompromised individuals and patients in intensive care units. Morbidity and mortality rates of these infections are high because of late diagnosis and delayed treatment. ...
Nanotechnological strategies for treatment of leishmaniasis-a review
(Journal of Biomedical Nanotechnology, 2017-02-01) [Resenha]
The World Health Organization (WHO) estimates that more than one billion people suffer from neglected tropical diseases. Leishmaniasis is a widespread disease, affecting 12 million people around the world with about 1-2 ...
Searching new antifungals: The use of in vitro and in vivo methods for evaluation of natural compounds
(Journal of Microbiological Methods, 2016-04-01) [Resenha]
In the last decades, the increased number of immunocompromised patients has led to the emergence of many forms of fungal infections. Furthermore, there are a restricted arsenal of antifungals available and an increase in ...
Highlights in endocytosis of nanostructured systems
(Current Medicinal Chemistry, 2017-06-01) [Resenha]
The focus of this review is the cellular internalisation mechanism of nanostructured systems (NSs) and their endosomal escape for targeted drug delivery. Endocytosis is a cellular process of internalisation of different ...
4 '-Aminochalcones As Novel Inhibitors of the Chlorinating Activity of Myeloperoxidase
(Current Medicinal Chemistry, 2012-11-01) [Resenha]
The excessive activation of neutrophils generates reactive oxygen species (ROS) and the secretion of primary granular enzymes, such as myeloperoxidase (MPO), which is implicated in numerous inflammatory diseases. The aim ...
Chemodiversity, Bioactivity and Chemosystematics of the Genus Inga (FABACEAE): A Brief Review
(Revista Virtual De Quimica, 2018-01-01) [Resenha]
The Inga genus belongs to the Fabaceae family, subfamily Mimosoideae, Ingeae tribe, and comprises about 300 species, whose name derives from the indigenous terminology Anga or inga, which in reality means seed is involved. ...