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Curcumin combined with metformin decreases glycemia and dyslipidemia, and increases paraoxonase activity in diabetic rats
(Diabetology and Metabolic Syndrome, 2019-04-30) [Artigo]
Background: Combination of current antidiabetic agents with natural antioxidants to manage diabetes mellitus and its complications has appeared as an emerging trend. Curcumin, a yellow pigment isolated from Curcuma longa ...
Transcriptomic crosstalk between fungal invasive pathogens and their host cells: Opportunities and challenges for next-generation sequencing methods
(Journal of Fungi, 2016-03-01) [Resenha]
Fungal invasive infections are an increasing health problem. The intrinsic complexity of pathogenic fungi and the unmet clinical need for new and more effective treatments requires a detailed knowledge of the infection ...
The lncRNA RMEL3 protects immortalized cells from serum withdrawal-induced growth arrest and promotes melanoma cell proliferation and tumor growth
(Pigment Cell and Melanoma Research, 2018-01-01) [Artigo]
RMEL3 is a recently identified lncRNA associated with BRAFV600E mutation and melanoma cell survival. Here, we demonstrate strong and moderate RMEL3 upregulation in BRAF and NRAS mutant melanoma cells, respectively, compared ...
New drugs with antiprotozoal activity from marine algae: a review
(Revista Brasileira de Farmacognosia, 2014-06-01) [Artigo]
The use of indigenous or remote popular knowledge to identify new drugs against diseases or infections is a well-known approach in medicine. The inhabitants of coastal regions are known to prepare algae extracts for the ...
First-void versus midstream urine culture for detection of Ureaplasma urealyticum in the urinary tract
(Revista de Microbiologia, 1995-07-01) [Artigo]
Quantitative Ureaplasma urealyticum culture was performed on clean first-void and midstream urine to evaluate the presence of these mollicutes in the urinary tract. The results, expressed as color changing units (CCU), ...
Infection and apparent invasion of Vero cells by Paracoccidioides brasiliensis
(Journal of Medical and Veterinary Mycology, 1994-01-01) [Artigo]
Paracoccidioides brasiliensis probably uses many different mechanisms to establish itself in the host and cause disease. In this work, we assess an in vitro model system which uses cultured mammalian cells to investigate ...
Frequency and genetic diversity of the MAT1 locus of Histoplasma capsulatum isolates in Mexico and Brazil
(Eukaryotic Cell, 2013-07-01) [Artigo]
The MAT1-1 and MAT1-2 idiomorphs associated with the MAT1 locus of Histoplasma capsulatum were identified by PCR. A total of 28 fungal isolates, 6 isolates from human clinical samples and 22 isolates from environmental ...
Bioaerossóis bacterianos em um hospital
(Revista de Ciências Farmacêuticas Básica e Aplicada, 2005-12-01) [Artigo]
Microbial contamination of an enclosed area may come from outside or be generated within the area itself. In the study described here, bioaerosol levels in hospital air were quantified and related to those found in the air ...
Effect of different pre-irradiation times on curcumin-mediated photodynamic therapy against planktonic cultures and biofilms of Candida spp
(Archives of Oral Biology, 2013-02-01) [Artigo]
Objectives: The aim of this study was to evaluate the effects of pre-irradiation time (PIT) on curcumin (Cur)-mediated photodynamic therapy (PDT) against planktonic and biofilm cultures of reference strains of Candida ...
Espectro de agentes etiológicos associados a surtos de doenças transmitidas por alimentos em núcleos receptores turísticos de três regiões geográficas do Estado de São Paulo
(Revista de Ciências Farmacêuticas Básica e Aplicada, 2007-12-01) [Artigo]
Foodborne and waterborne diseases are spread by the consumption of food or water contaminated with bacteria and/or their toxins, viruses, parasites or chemicals. The aim of the research reported here was to establish the ...