Now showing items 31-40 of 87
Preliminary evaluation of circulating microRNAs as potential biomarkers in paracoccidioidomycosis
(Biomedical Reports, 2017-03-01) [Artigo]
MicroRNAs (miRNAs) are small RNAs (length, 19-24 nucleotides) that regulate gene expression by either mRNA degradation or translational inhibition of proteins. Circulating miRNAs, which are extremely stable and protected ...
Antifungal and immunomodulatory activity of a novel cochleate for amphotericin B delivery against Sporothrix schenckii
(International Immunopharmacology, 2016-11-01) [Artigo]
Introduction: Sporotrichosis is an emergent subcutaneous mycoses caused by species of the Sporothrix schenckii complex. Amphotericin B (AmB) remains the main antifungal drug for the treatment of systemic infections, but ...
Drosophila ataxin-2 gene encodes two differentially expressed isoforms and its function in larval fat body is crucial for development of peripheral tissues
(FEBS Open Bio, 2016-11-01) [Artigo]
Different isoforms of ataxin-2 are predicted in Drosophila and may underlie different cellular processes. Here, we validated the isoforms B and C of Drosophila ataxin-2 locus (dAtx2), which we found to be expressed in ...
Synthesis, antioxidant and anti-inflammatory properties of an apocynin-derived dihydrocoumarin
(Medicinal Chemistry, 2017-01-01) [Artigo]
Background: Coumarin derivatives as dihydrocoumarins have been reported to have multiple biological activities, such as antioxidant and anti-inflammatory properties. Apocynin (APO), which is a substituted-methoxy-catechol, ...
Estudo do potencial antitumoral de cordialina a em sistema nanoemulsionado para tratamento de linhagens celulares de tumor cervical humano
(Revista de Ciencias Farmaceuticas Basica e Aplicada, 2017-01-01) [Nota]
Response of Cytokines and Hydrogen Peroxide to Sporothrix schenckii Exoantigen in Systemic Experimental Infection
(Mycopathologia, 2016-04-01) [Artigo]
The response of hydrogen peroxide (H2O2) and cytokines during an experimental sporotrichosis in male Swiss mice was assessed over a period of 10 weeks by monitoring macrophage activation challenged with exoantigen (ExoAg) ...
Evaluation of antimicrobial, cytotoxic and chemopreventive activities of carvone and its derivatives
(Brazilian Journal of Pharmaceutical Sciences, 2017-01-01) [Artigo]
Considering the reported activity of carvone in the literature, this study aimed to evaluate the antimicrobial, cytotoxic and chemopreventive activities of (+)- and (-)-carvone, (+)- and (-)- hydroxydihydrocarvone and ...
Candida auris: Epidemiology, risk factors, virulence, resistance, and therapeutic options
(Microbial Pathogenesis, 2018-12-01) [Resenha]
Candida auris emerged as a pathogen resistant to multiple antifungal and has been associated with nosocomial outbreaks with high transmission capacity between hospitalized individuals. C. auris was first described in 2009, ...
Alkyl Protocatechuate-Loaded Nanostructured Lipid Systems as a Treatment Strategy for Paracoccidioides brasiliensis and Paracoccidioides lutzii In Vitro
(Frontiers In Microbiology, 2017-06-12) [Artigo]
Dodecyl protocatechuate (dodecyl) is a derivative of protocatechuic acid (3,4dihydroxybenzoic acid) that possesses anti-oxidant and antifungal properties. Nanostructured lipid systems (NLS) can potentiate the action of ...
Influence of root-surface conditioning with acid and chelating agents on clot stabilization
(Quintessence International, 2010-04-01) [Artigo]
Objective: To compare the adhesion and maturation of blood components on chemically conditioned root surfaces. Method and Materials: Clinical root samples of human teeth were obtained (n = 150) and manually scaled. Five ...