Now showing items 1-10 of 42
Synthesis and characterization of an antibacterial and non-toxic dimeric peptide derived from the C-terminal region of Bothropstoxin-I
(Toxicon : Official Journal Of The International Society On Toxinology, 2015) [Artigo]
Infectious diseases are among the leading global causes of death, increasing the search for novel antibacterial agents. Among these, biologically active peptides are an excellent research tool. Using solid-phase peptide ...
Acute and subchronic antihyperglycemic activities of bowdichia virgilioides roots in non diabetic and diabetic rats
(Journal of Intercultural Ethnopharmacology, 2015) [Artigo]
Aim: The present study was undertaken to evaluate the acute and subchronic antihyperglycemic effects of methanolic extract of B. virgilioides root bark of B. virgilioides in streptozotocin-induced diabetic rats.Materials ...
A flow cytometry method for testing the susceptibility of Cryptococcus spp. to amphotericin B
(Revista Iberoamericana De Micología, 2015) [Artigo]
Human fungal infections have increased at an alarming rate in recent years, particularly in immunocompromised individuals. Cryptococcosis is the second most prevalent systemic fungal infection worldwide, and the most ...
In vitro Paracoccidioides brasiliensis biofilm and gene expression of adhesins and hydrolytic enzymes
(Virulence, 2015-08-18) [Artigo]
Paracoccidioides species are dimorphic fungi that initially infect the lungs but can also spread throughout the body. The spreading infection is most likely due to the formation of a biofilm that makes it difficult for the ...
Thiophenecarboxamide derivatives activated by EthA kill mycobacterium tuberculosis by inhibiting the CTP synthetase PyrG
(Chemistry & Biology, 2015-07-23) [Artigo]
To combat the emergence of drug-resistant strains of Mycobacterium tuberculosis, new antitubercular agents and novel drug targets are needed. Phenotypic screening of a library of 594 hit compounds uncovered two leads that ...
Advances and challenges in paracoccidioidomycosis serology caused by Paracoccidioides species complex: an update
(Diagnostic Microbiology And Infectious Disease, 2015) [Artigo]
Understanding the possible methodologies for the rapid and inexpensive identification of fungal infections is essential for disease diagnosis, but there are some limitations. To help with this problem, serological methods ...
Redox-active biflavonoids from Garcinia brasiliensis as inhibitors of neutrophil oxidative burst and human erythrocyte membrane damage
(Journal Of Ethnopharmacology, 2015-08-27) [Artigo]
Garcinia brasiliensis, a plant native to the Brazilian Amazon Rainforest, is used in traditional medicine to treat inflammation of the urinary tract, peptic ulcers, arthritis and other conditions. The purposes of this study ...
Evaluation of mutagenicity and metabolism-mediated cytotoxicity of the naphthoquinone 5-methoxy-3,4-dehydroxanthomegnin from Paepalanthus latipes (vol 25, pg 16, 2015)
(Revista Brasileira De Farmacognosia-brazilian Journal Of Pharmacognosy, 2015-05-01) [Errata]
Comparison of virulence between Paracoccidioides brasiliensis and Paracoccidioides lutzii using Galleria mellonella as a host model
(Virulence, 2015-01-01) [Artigo]
Paracoccidioidomycosis is a systemic mycosis, endemic in Latin America. The etiologic agents of this mycosis are composed of 2 species: Paracoccidioides brasiliensis and P. lutzii. Murine animal models are the gold standard ...
Functional analysis of Paracoccidioides brasiliensis 14-3-3 adhesin expressed in Saccharomyces cerevisiae Microbe-host interactions and microbial pathogenicity
(BMC Microbiology, 2015-11-04) [Artigo]
Background: 14-3-3 proteins comprise a family of eukaryotic multifunctional proteins involved in several cellular processes. The Pb14-3-3 of Paracoccidioides brasiliensis seems to play an important role in the Paracoccid ...