Now showing items 1-5 of 5
The reactivity of oytho-methoxy-substituted catechol radicals with sulfhydryl groups: Contribution for the comprehension of the mechanism of inhibition of NADPH oxidase by apocynin
(Biochemical Pharmacology, 2007-08-01) [Artigo]
Redox processes are involved in the mechanism of action of NADPH oxidase inhibitors such as diphenyleneiodonium and apocynin. Here, we studied the structure-activity relationship for apocynin and analogous ortho-methoxy- ...
The effect of pyrazinamide and rifampicin on isoniazid metabolism in rats
(Biopharmaceutics & Drug Disposition, 2007-09-01) [Artigo]
Hepatotoxicity is the main concern during tuberculosis chemotherapy with the first-line drugs isoniazid (INH), rifampicin (RMP) and pyrazinamide (PYR). Since these hepatotoxic events have been associated with INH metabolites, ...
The effect of rifampicin and pyrazinamide on isoniazid pharmacokinetics in rats
(Biopharmaceutics & Drug Disposition, 2007-11-01) [Artigo]
Tuberculosis chemotherapy involves combination of the drugs isoniazid (INH), rifampicin (RMP) and pyrazinamide (PYR) for a 6-month period. The present work investigated the influence of RMP and PYR on the pharmacokinetic ...
Chemiluminescent determination of leukocyte alkaline phosphatase: An advantageous alternative to the cytochemical assay
(Journal of Clinical Laboratory Analysis, 2007-01-01) [Artigo]
The determination of leukocyte alkaline phosphatasd (LAP) is used as an aid to diagnose many diseases in the laboratory. For example, it can be used to distinguish chronic myeloid leukemia (CML) from other myeloproliferative ...
The oxidation of apocynin catalyzed by myeloperoxidase: Proposal for NADPH oxidase inhibition
(Archives of Biochemistry and Biophysics, 2007-01-15) [Artigo]
Apocynin has been used as an efficient inhibitor of the NADPH oxidase complex and its mechanism of inhibition is linked to prior activation through the action of peroxidascs. Here we studied the oxidation of apocynin ...