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Now showing items 1-10 of 11
Thiophenecarboxamide derivatives activated by EthA kill mycobacterium tuberculosis by inhibiting the CTP synthetase PyrG
(Chemistry & Biology, 2015-07-23) [Artigo]
To combat the emergence of drug-resistant strains of Mycobacterium tuberculosis, new antitubercular agents and novel drug targets are needed. Phenotypic screening of a library of 594 hit compounds uncovered two leads that ...
Redox-active biflavonoids from Garcinia brasiliensis as inhibitors of neutrophil oxidative burst and human erythrocyte membrane damage
(Journal Of Ethnopharmacology, 2015-08-27) [Artigo]
Garcinia brasiliensis, a plant native to the Brazilian Amazon Rainforest, is used in traditional medicine to treat inflammation of the urinary tract, peptic ulcers, arthritis and other conditions. The purposes of this study ...
Hydrophobicity and antioxidant activity acting together for the beneficial health properties of nordihydroguaiaretic acid
(Food &function, 2015-01-01) [Artigo]
Nordihydroguaiaretic acid (NDGA) and rosmarinic acid (RA), phenolic compounds found in various plants and functional foods, have known antioxidant and anti-inflammatory properties. In the present study, we comparatively ...
Involvement of major components from sporothrix schenckii cell wall in the caspase-1 activation, nitric oxide and cytokines production during experimental sporotrichosis
(Mycopathologia, 2015-02-01) [Artigo]
Sporotrichosis is a chronic infection caused by the dimorphic fungus Sporothrix schenckii, involving all layers of skin and the subcutaneous tissue. The role of innate immune toll-like receptors 2 and 4 in the defense ...
C-2, N-dimethylbenzylamine cyclopalladated compounds: evaluation of cytotoxic, mutagenic and antitubercular activities
(Medicinal Chemistry Research, 2015-07-01) [Artigo]
Mono- and binuclear cyclometallated Pd(II) compounds containing C,N-chelating dimethylbenzylamine (Hdmba) have been synthesized aiming at investigating their mutagenic properties (Ames test) and cytotoxic activity toward ...
Adjuvants and delivery systems for antifungal vaccines: Current state and future developments
(Medical Mycology, 2015-01-01) [Resenha]
Mycoses are gaining increasing attention in modern medicine because of the increase in diseases associated with opportunistic fungal infections. Despite the recognized role of the immune system in the control of fungal ...
Could histoplasma capsulatum be related to healthcare-associated infections?
(Biomed Research International, 2015-01-01) [Resenha]
Healthcare-associated infections (HAI) are described in diverse settings. The main etiologic agents of HAI are bacteria (85%) and fungi (13%). Some factors increase the risk for HAI, particularly the use of medical devices; ...
Oil-in-water biocompatible microemulsion as a carrier for the antitumor drug compound methyl dihydrojasmonate
(International Journal Of Nanomedicine, 2015-01-01) [Artigo]
Methyl dihydrojasmonate (MJ) has been studied because of its application as an antitumor drug compound. However, as MJ is a poorly water-soluble compound, a suitable oil-in-water microemulsion (ME) has been studied in order ...
Influence of the Paracoccidioides brasiliensis 14-3-3 and gp43 proteins on the induction of apoptosis in A549 epithelial cells
(Memorias do Instituto Oswaldo Cruz, 2015-06-01) [Artigo]
The fungal strain Paracoccidioides brasiliensis remains viable inside of epithelial cells and can induce apoptosis in this population. However, until now, the molecules that participate in this process remained unknown. ...
Influence of daily consumption of synbiotic soy-based product supplemented with okara soybean by-product on risk factors for cardiovascular diseases
(Food Research International, 2015-07-01) [Artigo]
This study aimed to investigate the effect of a synbiotic fermented soy product supplemented with okara (a by-product from soybean) on cardiovascular disease risk markers in healthy men. In a randomized, double-blinded, ...