Now showing items 1-6 of 6
Anti-Immune Strategies of Pathogenic Fungi
(Frontiers In Cellular And Infection Microbiology, 2016-11-15) [Resenha]
Pathogenic fungi have developed many strategies to evade the host immune system. Multiple escape mechanisms appear to function together to inhibit attack by the various stages of both the adaptive and the innate immune ...
Antifungal and immunomodulatory activity of a novel cochleate for amphotericin B delivery against Sporothrix schenckii
(International Immunopharmacology, 2016-11-01) [Artigo]
Introduction: Sporotrichosis is an emergent subcutaneous mycoses caused by species of the Sporothrix schenckii complex. Amphotericin B (AmB) remains the main antifungal drug for the treatment of systemic infections, but ...
Drosophila ataxin-2 gene encodes two differentially expressed isoforms and its function in larval fat body is crucial for development of peripheral tissues
(FEBS Open Bio, 2016-11-01) [Artigo]
Different isoforms of ataxin-2 are predicted in Drosophila and may underlie different cellular processes. Here, we validated the isoforms B and C of Drosophila ataxin-2 locus (dAtx2), which we found to be expressed in ...
Response of Cytokines and Hydrogen Peroxide to Sporothrix schenckii Exoantigen in Systemic Experimental Infection
(Mycopathologia, 2016-04-01) [Artigo]
The response of hydrogen peroxide (H2O2) and cytokines during an experimental sporotrichosis in male Swiss mice was assessed over a period of 10 weeks by monitoring macrophage activation challenged with exoantigen (ExoAg) ...
A new dammarane saponin and other triterpenoids from Siolmatra brasiliensis and evaluation of the antidiabetic activity of its extract
(Pharmaceutical Biology, 2016-09-01) [Artigo]
ContextSiolmatra brasiliensis (Cogn.) Baill (Cucurbitaceae) is a climbing plant widely used for the treatment of diabetes mellitus symptoms.Objective This work evaluates the antidiabetic activity of an extract of S. ...
Synergistic effect of pedalitin and amphotericin B against Cryptococcus neoformans by in vitro and in vivo evaluation
(International Journal of Antimicrobial Agents, 2016-11-01) [Artigo]
Cryptococcosis is an opportunistic fungal infection responsible for high morbidity and mortality in immunocompromised patients. Combination of antifungal substances is a promising way to increase the percentage of successful ...