Search
Now showing items 1-10 of 20
Synthesis and characterization of an antibacterial and non-toxic dimeric peptide derived from the C-terminal region of Bothropstoxin-I
(Toxicon : Official Journal Of The International Society On Toxinology, 2015) [Artigo]
Infectious diseases are among the leading global causes of death, increasing the search for novel antibacterial agents. Among these, biologically active peptides are an excellent research tool. Using solid-phase peptide ...
Thiophenecarboxamide derivatives activated by EthA kill mycobacterium tuberculosis by inhibiting the CTP synthetase PyrG
(Chemistry & Biology, 2015-07-23) [Artigo]
To combat the emergence of drug-resistant strains of Mycobacterium tuberculosis, new antitubercular agents and novel drug targets are needed. Phenotypic screening of a library of 594 hit compounds uncovered two leads that ...
Redox-active biflavonoids from Garcinia brasiliensis as inhibitors of neutrophil oxidative burst and human erythrocyte membrane damage
(Journal Of Ethnopharmacology, 2015-08-27) [Artigo]
Garcinia brasiliensis, a plant native to the Brazilian Amazon Rainforest, is used in traditional medicine to treat inflammation of the urinary tract, peptic ulcers, arthritis and other conditions. The purposes of this study ...
Comparison of virulence between Paracoccidioides brasiliensis and Paracoccidioides lutzii using Galleria mellonella as a host model
(Virulence, 2015-01-01) [Artigo]
Paracoccidioidomycosis is a systemic mycosis, endemic in Latin America. The etiologic agents of this mycosis are composed of 2 species: Paracoccidioides brasiliensis and P. lutzii. Murine animal models are the gold standard ...
The 2',4'-dihydroxychalcone could be explored to develop new inhibitors against the glycerol-3-phosphate dehydrogenase from Leishmania species
(Bioorganic and Medicinal Chemistry Letters, 2015-09-01) [Artigo]
The enzyme glycerol-3-phosphate dehydrogenase (G3PDH) from Leishmania species is considered as an attractive target to design new antileishmanial drugs and a previous in silico study reported on the importance of chalcones ...
Pyrazolyl Pd(II) complexes containing triphenylphosphine: Synthesis and antimycobacterial activity
(Polyhedron, 2015-08-04) [Artigo]
Abstract Complexes of the type trans-[PdCl<inf>2</inf>(HL)(PPh<inf>3</inf>)], where HL = pyrazole (1); 3,5-dimethylpyrazole (2); 4-nitropyrazole (3); 4-iodopyrazole (4) and PPh<inf>3</inf> = triphenylphosphine, were ...
Sodium intake, brain c-Fos protein and gastric emptying in cell-dehydrated rats treated with methysergide into the lateral parabrachial nucleus
(Physiology & Behavior, 2015-11-01) [Artigo]
Previous studies from our laboratory have shown that methysergide, a serotonergic antagonist, injected into the lateral parabrachial nucleus (LPBN) combined with a pre-load of 2 M NaCl, given by gavage, induces 0.3 M NaCl ...
Effects of uremic solutes on reactive oxygen species in vitro model systems as a possibility of support the renal function management
(Bmc Nephrology, 2015-04-11) [Artigo]
Background: In view of the prevalence of oxidative stress in chronic kidney disease (CKD) patients, the loss of low-molecular-weight biomolecules by hemodialysis and the antioxidant potential of some uremic solutes that ...
Importance of adhesins in virulence of Paracoccidioides spp.
(Frontiers In Microbiology, 2015-04-10) [Artigo]
Members of the Paracoccidioides genus are the etiologic agents of paracoccidioidomycosis (PCM). This genus is composed of two species: Paracoccidioides brasiliensis and Paracoccidioides lutzii. The correct molecular taxonomic ...
Hydrophobicity and antioxidant activity acting together for the beneficial health properties of nordihydroguaiaretic acid
(Food &function, 2015-01-01) [Artigo]
Nordihydroguaiaretic acid (NDGA) and rosmarinic acid (RA), phenolic compounds found in various plants and functional foods, have known antioxidant and anti-inflammatory properties. In the present study, we comparatively ...