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Altered Ex Vivo Expression of Caspase 8, Caspase 9, and Bcl-2 Is Associated with T-Cell Hyporeactivity in Patients with Paracoccidioidomycosis
(Clinical and Vaccine Immunology, 2009-06-01) [Artigo]
To better understand the T-cell hyporesponsiveness of patients with paracoccidioidomycosis, we tested the hypothesis that the T cells were committed to apoptosis. We show here that T cells of patients with paracoccidioidomycosis ...
Induction of apoptosis in A549 pulmonary cells by two Paracoccidioides brasiliensis samples
(Memórias do Instituto Oswaldo Cruz, 2009-08-01) [Artigo]
Paracoccidioidomycosis presents a variety of clinical manifestations and Paracoccidioides brasiliensis can reach many tissues, most importantly the lungs. The ability of the pathogen to interact with host surface structures ...
Altered expression of the costimulatory molecules CD80, CD86, CD152, PD-1 and ICOS on T-cells from paracoccidioidomycosis patients: Lack of correlation with T-cell hyporesponsiveness
(Clinical Immunology, 2008-11-01) [Artigo]
T-cell proliferative hypo responsiveness, a hallmark of paracoccidioidomycosis immune responses, underlies host's failure in controlling fungus spread, being reversible with antifungal treatment. The mechanisms leading to ...
Enolase from Paracoccidioides brasiliensis: isolation and identification as a fibronectin-binding protein
(Journal of Medical Microbiology, 2009-06-01) [Artigo]
Paracoccidioides brasiliensis yeast cells can enter mammalian cells and may manipulate the host cell environment to favour their own growth and survival. Moreover, fibronectin and several other host extracellular matrix ...