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Doença arterial coronariana: Um novo paradigma na AIDS
(Revista de Ciencias Farmaceuticas, 2004-12-01) [Resenha]
The HIV-infected individuals have been identified as a peculiar group whose propensity to the development of abnormalities in lipids metabolism supports the hypothesis that AIDS itself can be considered as an independent ...
4 '-Aminochalcones As Novel Inhibitors of the Chlorinating Activity of Myeloperoxidase
(Current Medicinal Chemistry, 2012-11-01) [Resenha]
The excessive activation of neutrophils generates reactive oxygen species (ROS) and the secretion of primary granular enzymes, such as myeloperoxidase (MPO), which is implicated in numerous inflammatory diseases. The aim ...
Protocatechuic Acid Alkyl Esters: Hydrophobicity As a Determinant Factor for Inhibition of NADPH Oxidase
(Current Medicinal Chemistry, 2012-10-01) [Resenha]
This study presents the increased efficiency of NADPH oxidase inhibition produced by esterification of protocatechuic acid (P0). Alkyl esters bearing chain lengths of 4 (P4), 7 (P7) and 10 (P10) carbons were synthesized ...