Now showing items 1-10 of 15
Alchornea glandulosa Ethyl Acetate Fraction Exhibits Antiangiogenic Activity: Preliminary Findings from In Vitro Assays Using Human Umbilical Vein Endothelial Cells
(Journal of Medicinal Food, 2011-10-01) [Artigo]
Alchornea glandulosa has traditionally been used in Brazilian folk medicine for the treatment of immune-inflammatory diseases and as an antiulcer agent to heal gastric ulcer and gastritis. Angiogenesis is a complex multistep ...
Comparative study of disk diffusion and microdilution methods for evaluation of antifungal activity of natural compounds against medical yeasts Candida spp and Cryptococcus sp
(Revista de Ciências Farmacêuticas Básica e Aplicada, 2007-12-01) [Artigo]
Antifungal activity of natural products has been tested by adapting methods designed for synthetic drugs. In this study, two methods for the determination of antifungal activity of natural products, agar diffusion and broth ...
Evaluation of micronuclei frequency in Tradescantia pallida pollen mother cells treated with ethanolic extracts isolated from Cryptocarya mandioccana, Cryptocarya moschata and Pterogyne nitens
(Revista Brasileira de Toxicologia, 2007-12-01) [Artigo]
Although herbal extracts contain several classes of compounds with pharmacological activity, they also present toxic substances with mutagenic effects. The aim of the present study was to verify the mutagenicity of Cryptocarya ...
Chemopreventive activity of compounds extracted from Casearia sylvestris (Salicaceae) Sw against DNA damage induced by particulate matter emitted by sugarcane burning near Araraquara, Brazil
(Toxicology and Applied Pharmacology, 2012-12-15) [Artigo]
Ethanolic extract of Casearia sylvestris is thought to be antimutagenic. In this study, we attempted to determine whether this extract and casearin X (a clerodane diterpene from C. sylvestris) are protective against the ...
Anti-angiogenic effects of pterogynidine alkaloid isolated from Alchornea glandulosa
(BMC Complementary and Alternative Medicine, 2009-05-22) [Artigo]
Background: Angiogenesis, a complex multistep process that comprehends proliferation, migration and anastomosis of endothelial cells (EC), has a major role in the development of pathologic conditions such as inflammatory ...
4 '-Aminochalcones as novel inhibitor of the chlorinating activity of myeloperoxidase
(Planta Medica, 2012-08-01) [Resumo]
Biologically Active Eremophilane-Type Sesquiterpenes from Camarops sp., an Endophytic Fungus Isolated from Alibertia macrophylla
(Journal of Natural Products, 2014-03-01) [Artigo]
Two new eremophilane-type sesquiterpenes, xylarenones F (3) and G (4), have been isolated from solid substrate cultures of a Camarops sp. endophytic fungus isolated from Alibertia macrophylla, together with the known ...
The use of standard methodology for determination of antifungal activity of natural products against medical yeasts Candida sp and Cryptococcus sp
(Brazilian Journal of Microbiology, 2007-09-01) [Artigo]
Metodologias para determinar atividade antifúngica foram desenvolvidas com adaptações para avaliar produtos naturais. As mais usadas são bioautografia e o método de difusão em agar, que empregam meios de cultura complexos, ...
Bioactive Secondary Metabolites from Phomopsis sp., an Endophytic Fungus from Senna spectabilis
(Molecules, 2014-05-01) [Artigo]
Chemical investigation of an acetonitrile fraction from the endophytic fungus Phomopsis sp. led to the isolation of the new natural product 2-hydroxy-alternariol (7) together with the known compounds cytochalasins J (1) ...
4 '-Aminochalcones As Novel Inhibitors of the Chlorinating Activity of Myeloperoxidase
(Current Medicinal Chemistry, 2012-11-01) [Resenha]
The excessive activation of neutrophils generates reactive oxygen species (ROS) and the secretion of primary granular enzymes, such as myeloperoxidase (MPO), which is implicated in numerous inflammatory diseases. The aim ...