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Sodium intake, brain c-Fos protein and gastric emptying in cell-dehydrated rats treated with methysergide into the lateral parabrachial nucleus
(Physiology & Behavior, 2015-11-01) [Artigo]
Previous studies from our laboratory have shown that methysergide, a serotonergic antagonist, injected into the lateral parabrachial nucleus (LPBN) combined with a pre-load of 2 M NaCl, given by gavage, induces 0.3 M NaCl ...
Cryptomoschatone D2 from Cryptocarya mandioccana: cytotoxicity against human cervical carcinoma cell lines
(Revista de Ciências Farmacêuticas Básica e Aplicada, 2009) [Artigo]
Among the substances isolated from Cryptocarya sp, some styrylpyrones, such as goniothalamin, demonstrate antiproliferative activity in a broad range of human cell lines. In the present study, we assessed the cytotoxicity ...
Improvement of Pro-Oxidant Capacity of Protocatechuic Acid by Esterification
(Plos One, 2014-10-23) [Artigo]
Pro-oxidant effects of phenolic compounds are usually correlated to the one-electron redox potential of the phenoxyl radicals. Here we demonstrated that, besides their oxidizability, hydrophobicity can also be a decisive ...
New drugs with antiprotozoal activity from marine algae: a review
(Revista Brasileira de Farmacognosia, 2014-06-01) [Artigo]
The use of indigenous or remote popular knowledge to identify new drugs against diseases or infections is a well-known approach in medicine. The inhabitants of coastal regions are known to prepare algae extracts for the ...
Brief Report: The lincRNA Hotair Is Required for Epithelial-to-Mesenchymal Transition and Stemness Maintenance of Cancer Cell Lines
(Stem Cells, 2013-12-01) [Artigo]
Hotair is a member of the recently described class of noncoding RNAs called lincRNA (large intergenic noncoding RNA). Various studies suggest that Hotair acts regulating epigenetic states by recruiting chromatin-modifying ...
Modulation of HJURP (Holliday Junction-Recognizing Protein) Levels Is Correlated with Glioblastoma Cells Survival
(PLOS ONE, 2013-04-25) [Artigo]
Background: Diffuse astrocytomas are the most common type of primary brain cancer in adults. They present a wide variation in differentiation and aggressiveness, being classified into three grades: low-grade diffuse ...
The malate synthase of Paracoccidioides brasiliensis is a linked surface protein that behaves as an anchorless adhesin
(BMC Microbiology, 2009-12-24) [Artigo]
Background: The pathogenic fungus Paracoccidioides brasiliensis is the agent of paracoccidioidomycosis (PCM). This is a pulmonary mycosis acquired by inhalation of fungal airborne propagules that can disseminate to several ...
Streptococcus agalactiae in Brazil: serotype distribution, virulence determinants and antimicrobial susceptibility
(BMC Infectious Diseases, 2014-06-12) [Artigo]
Background: Group B Streptococcus (GBS) remains a major cause of neonatal sepsis and is also associated with invasive and noninvasive infections in pregnant women and non-pregnant adults, elderly and patients with underlying ...
Estudo fitoquímico de goiaba (Psidium guajava L.) com potencial antioxidante para o desenvolvimento de formulação fitocosmética
(Revista Brasileira de Farmacognosia, 2008-09-01) [Artigo]
Considerando-se a qualidade dos fitoterápicos, é importante salientar que a preocupação com esta questão inclui rigoroso acompanhamento das diferentes etapas do desenvolvimento e produção destes produtos, desde a coleta ...
Genotyping, serotyping and determination of mating-type of Cryptococcus neoformans clinical isolates from São Paulo State, Brazil
(Revista do Instituto de Medicina Tropical de São Paulo, 2007-02-01) [Artigo]
Cryptococcus neoformans, pertencente à classe dos basidiomicetos, é um importante patógeno, principalmente em pacientes imunocomprometidos. Neste estudo, 47 isolados clínicos de C. neoformans de várias regiões do Estado ...