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Sodium intake, brain c-Fos protein and gastric emptying in cell-dehydrated rats treated with methysergide into the lateral parabrachial nucleus
(Physiology & Behavior, 2015-11-01) [Artigo]
Previous studies from our laboratory have shown that methysergide, a serotonergic antagonist, injected into the lateral parabrachial nucleus (LPBN) combined with a pre-load of 2 M NaCl, given by gavage, induces 0.3 M NaCl ...
Caracterização molecular de estafilococos isolados de vacas com mastite subclínica e ordenhadores
(Arquivos do Instituto Biológico, 2012-12-01) [Artigo]
As bactérias isoladas para o estudo foram oriundas de 96 vacas (163 tetos positivos no California Mastitis Test - CMT e nove suabes de mão de ordenhadores, de nove propriedades rurais situadas no Município de Jataí, GO. ...
Cryptomoschatone D2 from Cryptocarya mandioccana: cytotoxicity against human cervical carcinoma cell lines
(Revista de Ciências Farmacêuticas Básica e Aplicada, 2009) [Artigo]
Among the substances isolated from Cryptocarya sp, some styrylpyrones, such as goniothalamin, demonstrate antiproliferative activity in a broad range of human cell lines. In the present study, we assessed the cytotoxicity ...
A recombinant enolase-montanide™ petgel a vaccine promotes a protective th1 immune response against a highly virulent sporothrix schenckii by toluene exposure
(Pharmaceutics, 2019-03-01) [Artigo]
The effect of vaccination in fungal strains that suffered changes in their virulence by exposure to environmental contaminants is largely known. Growing reports of resistance to antifungal drugs and the emergence of new ...
Improvement of Pro-Oxidant Capacity of Protocatechuic Acid by Esterification
(Plos One, 2014-10-23) [Artigo]
Pro-oxidant effects of phenolic compounds are usually correlated to the one-electron redox potential of the phenoxyl radicals. Here we demonstrated that, besides their oxidizability, hydrophobicity can also be a decisive ...
The lncRNA RMEL3 protects immortalized cells from serum withdrawal-induced growth arrest and promotes melanoma cell proliferation and tumor growth
(Pigment Cell and Melanoma Research, 2018-01-01) [Artigo]
RMEL3 is a recently identified lncRNA associated with BRAFV600E mutation and melanoma cell survival. Here, we demonstrate strong and moderate RMEL3 upregulation in BRAF and NRAS mutant melanoma cells, respectively, compared ...
New drugs with antiprotozoal activity from marine algae: a review
(Revista Brasileira de Farmacognosia, 2014-06-01) [Artigo]
The use of indigenous or remote popular knowledge to identify new drugs against diseases or infections is a well-known approach in medicine. The inhabitants of coastal regions are known to prepare algae extracts for the ...
Brief Report: The lincRNA Hotair Is Required for Epithelial-to-Mesenchymal Transition and Stemness Maintenance of Cancer Cell Lines
(Stem Cells, 2013-12-01) [Artigo]
Hotair is a member of the recently described class of noncoding RNAs called lincRNA (large intergenic noncoding RNA). Various studies suggest that Hotair acts regulating epigenetic states by recruiting chromatin-modifying ...
Modulation of HJURP (Holliday Junction-Recognizing Protein) Levels Is Correlated with Glioblastoma Cells Survival
(PLOS ONE, 2013-04-25) [Artigo]
Background: Diffuse astrocytomas are the most common type of primary brain cancer in adults. They present a wide variation in differentiation and aggressiveness, being classified into three grades: low-grade diffuse ...
Genotyping, serotyping and determination of mating-type of Cryptococcus neoformans clinical isolates from São Paulo State, Brazil
(Revista do Instituto de Medicina Tropical de São Paulo, 2007-02-01) [Artigo]
Cryptococcus neoformans, pertencente à classe dos basidiomicetos, é um importante patógeno, principalmente em pacientes imunocomprometidos. Neste estudo, 47 isolados clínicos de C. neoformans de várias regiões do Estado ...