Now showing items 21-30 of 74
Correlation among Antioxidant, Antimicrobial, Hemolytic, and Antiproliferative Properties of Leiothrix spiralis Leaves Extract
(International Journal of Molecular Sciences, 2012-07-01) [Artigo]
The biological activities of a plant extract depend on a complex sum of individual properties including the antioxidant activity. Several biological activities protect against the harmful action of reactive oxygen species ...
Alkaloids extracted from Pterogyne nitens induce apoptosis in malignant breast cell line
(Tumor Biology, 2010-10-01) [Artigo]
In the present study, two alkaloids isolated from Pterogyne nitens, a plant native to Brazil, have been shown to induce apoptosis in human breast cancer cells. These compounds, pterogynine (PGN) and pterogynidine (PGD), ...
Evaluation of micronuclei frequency in Tradescantia pallida pollen mother cells treated with ethanolic extracts isolated from Cryptocarya mandioccana, Cryptocarya moschata and Pterogyne nitens
(Revista Brasileira de Toxicologia, 2007-12-01) [Artigo]
Although herbal extracts contain several classes of compounds with pharmacological activity, they also present toxic substances with mutagenic effects. The aim of the present study was to verify the mutagenicity of Cryptocarya ...
Indole ring oxidation by activated leukocytes prevents the production of hypochlorous acid
(Brazilian Journal of Medical and Biological Research, 2005-11-01) [Artigo]
Hypochlorous acid (HOCl) released by activated leukocytes has been implicated in the tissue damage that characterizes chronic inflammatory diseases. In this investigation, 14 indole derivatives, including metabolites such ...
Chemopreventive activity of compounds extracted from Casearia sylvestris (Salicaceae) Sw against DNA damage induced by particulate matter emitted by sugarcane burning near Araraquara, Brazil
(Toxicology and Applied Pharmacology, 2012-12-15) [Artigo]
Ethanolic extract of Casearia sylvestris is thought to be antimutagenic. In this study, we attempted to determine whether this extract and casearin X (a clerodane diterpene from C. sylvestris) are protective against the ...
Profile of Maytenus aquifolium action over free radicals and reactive oxygen species
(Revista Brasileira de Ciencias Farmaceuticas/Brazilian Journal of Pharmaceutical Sciences, 2007-07-01) [Artigo]
Reactive oxygen species (ROS) and free radical species have been implicated in initiating, accompanying or causing many diseases in living organisms; there is thus, a continual need for antioxidants molecules to inactivate ...
CCR5 genotype and plasma ß-chemokine concentration of Brazilian HIV-infected individuals
(Brazilian Journal of Medical and Biological Research, 2002-11-01) [Artigo]
The 32-bp deletion in the HIV-1 co-receptor CCR5 confers a high degree of resistance to HIV-1 infection in homozygous individuals for the deleted allele and partial protection against HIV-1 during disease progression in ...
Does cotinine act upon reactive oxygen species and peroxidases?
(Eclética Química, 2007-06-19) [Artigo]
Nicotine, an oxidizing agent, is certainly one of the most widely used alkaloids in the world. It is, together with its main metabolite, cotinine, responsible for tobacco-dependence. The use of tobacco is closely associated ...
Immunomodulatory and cytotoxic effects of palladium(II) complexes in Ehrlich ascites tumor
(Annual Review of Biomedical Sciences, 2005) [Artigo]
Antioxidant activity of Maytenus ilicifolia root bark
(Fitoterapia, 2006-04-01) [Artigo]
Maytenus ilicifolia is an important plant with potential on cancer treatment and has been largely used in Brazil and other countries. We have evaluated the crude ethanolic extract of M. ilicifolia as a potential antioxidant ...