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dc.contributor.authorPuga, Guilherme Morais [UNESP]
dc.contributor.authorNovais, Iane de Paiva [UNESP]
dc.contributor.authorZanesco, Angelina [UNESP]
dc.date.accessioned2014-05-27T11:25:52Z
dc.date.available2014-05-27T11:25:52Z
dc.date.issued2011-05-01
dc.identifier.citationArquivos de Medicina, v. 25, n. 3, p. 107-114, 2011.
dc.identifier.issn0871-3413
dc.identifier.urihttp://hdl.handle.net/11449/72416
dc.description.abstractNitric oxide is synthesized from L-arginine and plays an important role in blood pressure regulation, platelets aggregation and atherosclerosis development. Most of the studies have shown that the beneficial effects of the L-arginine supplementation are related to an increasing of nitric oxide bioavailability to the cells, improving the endothelial dysfunction, decreasing oxidative stress, ameliorating lipid profile and insulin resistance. However some studies show conflicting results. Considering the role of the endothelium on the pathogenesis of the cardiovascular diseases as well as on the endocrine-metabolic diseases, this review will update studies involving the role of nitric oxide and its signaling pathways in the regulation of vascular function. Furthermore, this review will focus on the main results of the clinical trials using oral L-arginine supplementation, with or without physical exercise, in an attempt to obtain beneficial effects on the cardiovascular and endocrine-metabolic systems in patients and healthy subjects.en
dc.format.extent107-114
dc.language.isoeng
dc.language.isopor
dc.relation.ispartofArquivos de Medicina
dc.sourceScopus
dc.subjectAtherosclerosis
dc.subjectCardiovascular diseases
dc.subjectL-arginine
dc.subjectNitric oxide
dc.subjectarginine
dc.subjectnitric oxide
dc.subjectatherosclerosis
dc.subjectbioavailability
dc.subjectblood pressure regulation
dc.subjectcardiovascular disease
dc.subjectendocrine disease
dc.subjectendothelial dysfunction
dc.subjectexercise
dc.subjecthuman
dc.subjectinsulin resistance
dc.subjectlipid analysis
dc.subjectmetabolic disorder
dc.subjectoxidative stress
dc.subjectprotein analysis
dc.subjectprotein function
dc.subjectreview
dc.subjectthrombocyte aggregation
dc.titleEfeitos terapêuticos da suplementação de L-arginina nas doenças cardiovasculares e endócrino-metabólicaspt
dc.title.alternativeTherapeutic effects of L-arginine supplementation on the cardiovascular and endocrine -metabolic diseasesen
dc.typeResenha
dcterms.licensehttp://www.scielo.gpeari.mctes.pt/revistas/am/paboutj.htm
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationInstituto de Biociências Universidade Estadual Paulista, Rio Claro (SP)
dc.description.affiliationUnespInstituto de Biociências Universidade Estadual Paulista, Rio Claro (SP)
dc.rights.accessRightsAcesso restrito
dc.identifier.scopus2-s2.0-84857463140
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Rio Claropt
dc.identifier.lattes4472007237545596
unesp.author.lattes4472007237545596
dc.relation.ispartofsjr0,103
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